Australian family physician · 2008
Flucloxacillin induced acute renal failure.
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Xu Bo, Murray Michael
Аннотация
BACKGROUND: Acute interstitial nephritis is a less frequently reported adverse effect of flucloxacillin compared with other well known associations such as hepatotoxicity.
OBJECTIVE: This article describes the conservative management of a case of flucloxacillin induced acute renal failure, and reviews the available evidence on the treatment of drug induced acute interstitial nephritis, including the use of corticosteroids.
DISCUSSION: Drug induced acute interstitial nephritis can be managed conservatively by cessation of the suspected offending drug in many cases. Referral should be made to a nephrologist, with consideration given to renal biopsy, followed by trial of corticosteroids, if renal function does not improve within 7 days of drug cessation.
OBJECTIVE: This article describes the conservative management of a case of flucloxacillin induced acute renal failure, and reviews the available evidence on the treatment of drug induced acute interstitial nephritis, including the use of corticosteroids.
DISCUSSION: Drug induced acute interstitial nephritis can be managed conservatively by cessation of the suspected offending drug in many cases. Referral should be made to a nephrologist, with consideration given to renal biopsy, followed by trial of corticosteroids, if renal function does not improve within 7 days of drug cessation.