Медицинская библиотека · medRxiv : the preprint server for health sciences · 2020

Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.

Lee Ivan T, Nakayama Tsuguhisa, Wu Chien-Ting, Goltsev Yury, Jiang Sizun, Gall Phillip A, Liao Chun-Kang, Shih Liang-Chun, Schürch Christian M, McIlwain David R, Chu Pauline, Borchard Nicole A, Zarabanda David, Dholakia Sachi S, Yang Angela, Kim Dayoung, Kanie Tomoharu, Lin Chia-Der, Tsai Ming-Hsui, Phillips Katie M, Kim Raymond, Overdevest Jonathan B, Tyler Matthew A, Yan Carol H, Lin Chih-Feng, Lin Yi-Tsen, Bau Da-Tian, Tsay Gregory J, Patel Zara M, Tsou Yung-An, Tai Chih-Jaan, Yeh Te-Huei, Hwang Peter H, Nolan Garry P, Nayak Jayakar V, Jackson Peter K

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We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.

Для цитирования: Lee Ivan T, Nakayama Tsuguhisa, Wu Chien-Ting, Goltsev Yury, Jiang Sizun, Gall Phillip A, Liao Chun-Kang, Shih Liang-Chun, Schürch Christian M, McIlwain David R, Chu Pauline, Borchard Nicole A, Zarabanda David, Dholakia Sachi S, Yang Angela, Kim Dayoung, Kanie Tomoharu, Lin Chia-Der, Tsai Ming-Hsui, Phillips Katie M, Kim Raymond, Overdevest Jonathan B, Tyler Matthew A, Yan Carol H, Lin Chih-Feng, Lin Yi-Tsen, Bau Da-Tian, Tsay Gregory J, Patel Zara M, Tsou Yung-An, Tai Chih-Jaan, Yeh Te-Huei, Hwang Peter H, Nolan Garry P, Nayak Jayakar V, Jackson Peter K. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.. medRxiv : the preprint server for health sciences. 2020. DOI: 10.1101/2020.05.08.20092866.

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