The Journal of infectious diseases · 2020
Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge.
СтатьяНазвание и аннотация: Перевод в очереди
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Lo Michael K, Spengler Jessica R, Krumpe Lauren R H, Welch Stephen R, Chattopadhyay Anasuya, Harmon Jessica R, Coleman-McCray JoAnn D, Scholte Florine E M, Hotard Anne L, Fuqua Joshua L, Rose John K, Nichol Stuart T, Palmer Kenneth E, O'Keefe Barry R, Spiropoulou Christina F
Аннотация
Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved therapeutic for human use against NiV infection. Griffithsin (GRFT) is high-mannose oligosaccharide binding lectin that has shown in vivo broad-spectrum activity against viruses, including severe acute respiratory syndrome coronavirus, human immunodeficiency virus 1, hepatitis C virus, and Japanese encephalitis virus. In this study, we evaluated the in vitro antiviral activities of GRFT and its synthetic trimeric tandemer (3mG) against NiV and other viruses from 4 virus families. The 3mG had comparatively greater potency than GRFT against NiV due to its enhanced ability to block NiV glycoprotein-induced syncytia formation. Our initial in vivo prophylactic evaluation of an oxidation-resistant GRFT (Q-GRFT) showed significant protection against lethal NiV challenge in Syrian golden hamsters. Our results warrant further development of Q-GRFT and 3mG as potential NiV therapeutics.