Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 1998
Hyperthyroidism during lithium therapy for depression.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Dwarakanathan A A
Аннотация
OBJECTIVE: To report three cases of hyperthyroidism encountered within a period of 32 months in patients receiving lithium therapy for depression.
METHODS: Three detailed case reports are presented, and the related literature is discussed.
RESULTS: Although hypothyroidism during lithium therapy is well recognized and documented, appearance of cases of hyperthyroidism during lithium therapy is considered uncommon. The antithyroid effect of lithium through inhibition of generation of cyclic adenosine monophosphate tends to mask the underlying hyperthyroidism. Nevertheless, during a 32-month period, three cases of hyperthyroidism were encountered in patients who had received lithium treatment (900 to 1,200 mg/day) for 7 months to 17 years. These patients had symptoms of heat intolerance, palpitations, and tremor, and they were subsequently treated successfully with radioactive iodine.
CONCLUSION: Most likely, cases of hyperthyroidism that occur during lithium therapy may be under-diagnosed, underreported, or both.
METHODS: Three detailed case reports are presented, and the related literature is discussed.
RESULTS: Although hypothyroidism during lithium therapy is well recognized and documented, appearance of cases of hyperthyroidism during lithium therapy is considered uncommon. The antithyroid effect of lithium through inhibition of generation of cyclic adenosine monophosphate tends to mask the underlying hyperthyroidism. Nevertheless, during a 32-month period, three cases of hyperthyroidism were encountered in patients who had received lithium treatment (900 to 1,200 mg/day) for 7 months to 17 years. These patients had symptoms of heat intolerance, palpitations, and tremor, and they were subsequently treated successfully with radioactive iodine.
CONCLUSION: Most likely, cases of hyperthyroidism that occur during lithium therapy may be under-diagnosed, underreported, or both.