Asian Pacific journal of cancer prevention : APJCP · 2016
Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Abdelgawad Iman A, Radwan Noha H, Shafik Roxan E, Shokralla Hala A
Аннотация
BACKGROUND: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones.
AIM: The objectives of the present study were to investigate the circulating levels of BAFF , IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival.
MATERIALS AND METHODS: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients.
RESULTS: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels.
CONCLUSIONS: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
AIM: The objectives of the present study were to investigate the circulating levels of BAFF , IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival.
MATERIALS AND METHODS: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients.
RESULTS: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels.
CONCLUSIONS: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.