Intensive care medicine · 2003
Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia.
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Wood G Christopher, Hanes Scott D, Boucher Bradley A, Croce Martin A, Fabian Timothy C
Аннотация
OBJECTIVE: To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).
DESIGN: Observational case series.
SETTING: . The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.
PATIENTS AND PARTICIPANTS: Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.
INTERVENTIONS: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.
MEASUREMENTS AND RESULTS: Doxycycline or minocycline was successful in six of seven patients.
CONCLUSIONS: Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.
DESIGN: Observational case series.
SETTING: . The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.
PATIENTS AND PARTICIPANTS: Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.
INTERVENTIONS: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.
MEASUREMENTS AND RESULTS: Doxycycline or minocycline was successful in six of seven patients.
CONCLUSIONS: Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.
Предметные рубрики MeSH
APACHEAcinetobacter InfectionsAcinetobacter baumanniiAdolescentAdultAgedAnti-Bacterial AgentsBronchoalveolar Lavage FluidCritical CareCritical IllnessCross InfectionDoxycyclineDrug Resistance, Multiple, BacterialHumansInfection ControlInfusions, IntravenousMicrobial Sensitivity TestsMiddle AgedMinocyclinePneumonia, BacterialRespiration, ArtificialRetrospective StudiesTennesseeTrauma CentersTreatment Outcome