Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia.

OBJECTIVE

To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).

DESIGN

Observational case series.

SETTING

. The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.

PATIENTS AND

PARTICIPANTS

Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.

INTERVENTIONS: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.

MEASUREMENTS AND

RESULTS

Doxycycline or minocycline was successful in six of seven patients.

CONCLUSIONS

Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.