Experiment and Simulation Study of Automatic Temperature Control FAIMS Chip.

The temperature of the carrier gas will affect the performance of high-field asymmetric ion waveform mobility spectrometry (FAIMS), changing the height and position of the peaks of the FAIMS spectrum. In this study, we explored the influence of temperature on the FAIMS spectrum through experiment and simulation. In the experiment, the PCB self-heating temperature control FAIMS system was used to study the effects of temperature changes on the FAIMS spectra of ethanol, acetic acid, acetone, and ethyl acetate, and the coefficient solving methods of mobility a2 and a4 were derived in detail. Based on the experimental data, the mobility coefficients a2 and a4 were solved and replaced by the simulation software SIMION. The results show that as the temperature increases, the peak height of the spectrum of FAIMS decreases, and there will be a certain amount of offset in the position of the peaks in the spectrum. Through simulation, it is found that during the heating process, the number of ions decreases from approximately 60 to 6, and the compensation voltages of acetone, ethanol, acetic acid, and ethyl acetate change by about 1.1, 0.7, 0.3, and 0.1 V, respectively. This study provides a detailed solution process for the calculation of the ion mobility coefficients in the SIMION simulation, and the use of temperature control can effectively improve the resolution and accuracy of FAIMS in volatile organic compounds (VOCs) detection.