An innovative hybrid approach for detection of pacemaker pulses at low sampling frequency.

Accurate assessment of pacemaker function or malfunction is essential to make clinical interpretations on pacemaker therapy and patient symptoms. This article presents an innovative approach for detecting pacemaker pulses at sampling frequency as low as 125Hz. The proposed method is validated in wide range of simulated clinical ECG conditions such as arrhythmia (sinus rhythms, supraventricular rhythms, and AV blocks), pulse amplitudes (~100µV to ~3mV), pulse durations (~100µs to ~2ms), pacemaker modes and types (fixed-rate or on-demand single chamber, dual chamber, and bi-ventricular pacing), and physiological noise (tremor). The proposed algorithm demonstrates clinically acceptable detection accuracies with sensitivity and PPV of 98.1 ± 4.4 % and 100 %, respectively. In conclusion, the approach is well suited for integration in long-term wearable ECG sensor devices operating at a low sample frequency to monitor pacemaker function.Clinical Relevance- The proposed system enables real-time long-term continuous assessment of the proper functioning of implanted pacemaker and progression of treatment for cardiac conditions using battery-powered wearable ECG monitors.