Active pre-term management of severe osteogenesis imperfecta.

Some of the advantages of using an intra-amniotic injection of urea combined with prostaglandins for mid trimester termination include an extremely high success rate, a mean time of approximately 10 hours and delivery of a dead fetus. The successful application of this method for the active pre-term management of patients in whom severe fetal abnormality, such as that reported here, suggests this technique of inducing abortion and labour deserves further consideration in those special circumstances where the obstetrician is anxious that the pregnancy should be interrupted despite the gestation length and where a live birth should not occur.