Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021
Comparison of X-ray absorption spectra from copper-loaded bovine and ovine livers.
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Clarkson A H, Kendall N R
Аннотация
BACKGROUND: Copper toxicity and hepatic copper accumulation pose a serious risk to ruminant health and production. Differences in the copper-handling mechanisms of cattle and sheep have been noted, not only in comparison to each other, but also in comparison to 'copper-tolerant' monogastric species. Ruminants appear less able to cope with rising liver copper concentration than monogastric counterparts, with sheep in general less able to cope with elevated copper intake than cattle.
METHODS: X-ray absorption spectroscopy (XAS) was used to investigate the differences between the livers of these species at high copper status.
RESULTS: The X-ray absorption fine structure (XAFS) and X-ray absorption near edge structure (XANES) spectra indicated that the hepatic copper compound is most likely to be bound to metallothionein; consistent with monogastric species.
CONCLUSION: Although, most likely stored as copper-metallothionein, there may be a role for glutathione as a short-term, intermediate copper buffer which may have more relevance to sheep than cattle. The potential that thiomolybdate bound copper can be stored in the liver could not be ruled out.
METHODS: X-ray absorption spectroscopy (XAS) was used to investigate the differences between the livers of these species at high copper status.
RESULTS: The X-ray absorption fine structure (XAFS) and X-ray absorption near edge structure (XANES) spectra indicated that the hepatic copper compound is most likely to be bound to metallothionein; consistent with monogastric species.
CONCLUSION: Although, most likely stored as copper-metallothionein, there may be a role for glutathione as a short-term, intermediate copper buffer which may have more relevance to sheep than cattle. The potential that thiomolybdate bound copper can be stored in the liver could not be ruled out.