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DOI 10.1038/s41588-023-01520-w

Медицинская библиотека · Nature genetics · 2023

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.

Beaumont Robin N, Flatley Christopher, Vaudel Marc, Wu Xiaoping, Chen Jing, Moen Gunn-Helen, Skotte Line, Helgeland Øyvind, Solé-Navais Pol, Banasik Karina, Albiñana Clara, Ronkainen Justiina, Fadista João, Stinson Sara Elizabeth, Trajanoska Katerina, Wang Carol A, Westergaard David, Srinivasan Sundararajan, Sánchez-Soriano Carlos, Bilbao Jose Ramon, Allard Catherine, Groleau Marika, Kuulasmaa Teemu, Leirer Daniel J, White Frédérique, Jacques Pierre-Étienne, Cheng Haoxiang, Hao Ke, Andreassen Ole A, Åsvold Bjørn Olav, Atalay Mustafa, Bhatta Laxmi, Bouchard Luigi, Brumpton Ben Michael, Brunak Søren, Bybjerg-Grauholm Jonas, Ebbing Cathrine, Elliott Paul, Engelbrechtsen Line, Erikstrup Christian, Estarlich Marisa, Franks Stephen, Gaillard Romy, Geller Frank, Grove Jakob, Hougaard David M, Kajantie Eero, Morgen Camilla S, Nohr Ellen A, Nyegaard Mette, Palmer Colin N A, Pedersen Ole Birger, Early Growth Genetics (EGG) Consortium, Rivadeneira Fernando, Sebert Sylvain, Shields Beverley M, Stoltenberg Camilla, Surakka Ida, Thørner Lise Wegner, Ullum Henrik, Vaarasmaki Marja, Vilhjalmsson Bjarni J, Willer Cristen J, Lakka Timo A, Gybel-Brask Dorte, Bustamante Mariona, Hansen Torben, Pearson Ewan R, Reynolds Rebecca M, Ostrowski Sisse R, Pennell Craig E, Jaddoe Vincent W V, Felix Janine F, Hattersley Andrew T, Melbye Mads, Lawlor Deborah A, Hveem Kristian, Werge Thomas, Nielsen Henriette Svarre, Magnus Per, Evans David M, Jacobsson Bo, Järvelin Marjo-Riitta, Zhang Ge, Hivert Marie-France, Johansson Stefan, Freathy Rachel M, Feenstra Bjarke, Njølstad Pål R

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Аннотация

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.

Для цитирования: Beaumont Robin N, Flatley Christopher, Vaudel Marc, Wu Xiaoping, Chen Jing, Moen Gunn-Helen, Skotte Line, Helgeland Øyvind, Solé-Navais Pol, Banasik Karina, Albiñana Clara, Ronkainen Justiina, Fadista João, Stinson Sara Elizabeth, Trajanoska Katerina, Wang Carol A, Westergaard David, Srinivasan Sundararajan, Sánchez-Soriano Carlos, Bilbao Jose Ramon, Allard Catherine, Groleau Marika, Kuulasmaa Teemu, Leirer Daniel J, White Frédérique, Jacques Pierre-Étienne, Cheng Haoxiang, Hao Ke, Andreassen Ole A, Åsvold Bjørn Olav, Atalay Mustafa, Bhatta Laxmi, Bouchard Luigi, Brumpton Ben Michael, Brunak Søren, Bybjerg-Grauholm Jonas, Ebbing Cathrine, Elliott Paul, Engelbrechtsen Line, Erikstrup Christian, Estarlich Marisa, Franks Stephen, Gaillard Romy, Geller Frank, Grove Jakob, Hougaard David M, Kajantie Eero, Morgen Camilla S, Nohr Ellen A, Nyegaard Mette, Palmer Colin N A, Pedersen Ole Birger, Early Growth Genetics (EGG) Consortium, Rivadeneira Fernando, Sebert Sylvain, Shields Beverley M, Stoltenberg Camilla, Surakka Ida, Thørner Lise Wegner, Ullum Henrik, Vaarasmaki Marja, Vilhjalmsson Bjarni J, Willer Cristen J, Lakka Timo A, Gybel-Brask Dorte, Bustamante Mariona, Hansen Torben, Pearson Ewan R, Reynolds Rebecca M, Ostrowski Sisse R, Pennell Craig E, Jaddoe Vincent W V, Felix Janine F, Hattersley Andrew T, Melbye Mads, Lawlor Deborah A, Hveem Kristian, Werge Thomas, Nielsen Henriette Svarre, Magnus Per, Evans David M, Jacobsson Bo, Järvelin Marjo-Riitta, Zhang Ge, Hivert Marie-France, Johansson Stefan, Freathy Rachel M, Feenstra Bjarke, Njølstad Pål R. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.. Nature genetics. 2023. DOI: 10.1038/s41588-023-01520-w.

Предметные рубрики MeSH

FemaleHumansPregnancyBirth WeightFetal DevelopmentGenome-Wide Association StudyInsulinPlacentaMale
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