Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Tobias Deirdre K, Merino Jordi, Ahmad Abrar, Aiken Catherine, Benham Jamie L, Bodhini Dhanasekaran, Clark Amy L, Colclough Kevin, Corcoy Rosa, Cromer Sara J, Duan Daisy, Felton Jamie L, Francis Ellen C, Gillard Pieter, Gingras Véronique, Gaillard Romy, Haider Eram, Hughes Alice, Ikle Jennifer M, Jacobsen Laura M, Kahkoska Anna R, Kettunen Jarno L T, Kreienkamp Raymond J, Lim Lee-Ling, Männistö Jonna M E, Massey Robert, Mclennan Niamh-Maire, Miller Rachel G, Morieri Mario Luca, Most Jasper, Naylor Rochelle N, Ozkan Bige, Patel Kashyap Amratlal, Pilla Scott J, Prystupa Katsiaryna, Raghavan Sridharan, Rooney Mary R, Schön Martin, Semnani-Azad Zhila, Sevilla-Gonzalez Magdalena, Svalastoga Pernille, Takele Wubet Worku, Tam Claudia Ha-Ting, Thuesen Anne Cathrine B, Tosur Mustafa, Wallace Amelia S, Wang Caroline C, Wong Jessie J, Yamamoto Jennifer M, Young Katherine, Amouyal Chloé, Andersen Mette K, Bonham Maxine P, Chen Mingling, Cheng Feifei, Chikowore Tinashe, Chivers Sian C, Clemmensen Christoffer, Dabelea Dana, Dawed Adem Y, Deutsch Aaron J, Dickens Laura T, DiMeglio Linda A, Dudenhöffer-Pfeifer Monika, Evans-Molina Carmella, Fernández-Balsells María Mercè, Fitipaldi Hugo, Fitzpatrick Stephanie L, Gitelman Stephen E, Goodarzi Mark O, Grieger Jessica A, Guasch-Ferré Marta, Habibi Nahal, Hansen Torben, Huang Chuiguo, Harris-Kawano Arianna, Ismail Heba M, Hoag Benjamin, Johnson Randi K, Jones Angus G, Koivula Robert W, Leong Aaron, Leung Gloria K W, Libman Ingrid M, Liu Kai, Long S Alice, Lowe William L, Morton Robert W, Motala Ayesha A, Onengut-Gumuscu Suna, Pankow James S, Pathirana Maleesa, Pazmino Sofia, Perez Dianna, Petrie John R, Powe Camille E, Quinteros Alejandra, Jain Rashmi, Ray Debashree, Ried-Larsen Mathias, Saeed Zeb, Santhakumar Vanessa, Kanbour Sarah, Sarkar Sudipa, Monaco Gabriela S F, Scholtens Denise M, Selvin Elizabeth, Sheu Wayne Huey-Herng, Speake Cate, Stanislawski Maggie A, Steenackers Nele, Steck Andrea K, Stefan Norbert, Støy Julie, Taylor Rachael, Tye Sok Cin, Ukke Gebresilasea Gendisha, Urazbayeva Marzhan, Van der Schueren Bart, Vatier Camille, Wentworth John M, Hannah Wesley, White Sara L, Yu Gechang, Zhang Yingchai, Zhou Shao J, Beltrand Jacques, Polak Michel, Aukrust Ingvild, de Franco Elisa, Flanagan Sarah E, Maloney Kristin A, McGovern Andrew, Molnes Janne, Nakabuye Mariam, Njølstad Pål Rasmus, Pomares-Millan Hugo, Provenzano Michele, Saint-Martin Cécile, Zhang Cuilin, Zhu Yeyi, Auh Sungyoung, de Souza Russell, Fawcett Andrea J, Gruber Chandra, Mekonnen Eskedar Getie, Mixter Emily, Sherifali Diana, Eckel Robert H, Nolan John J, Philipson Louis H, Brown Rebecca J, Billings Liana K, Boyle Kristen, Costacou Tina, Dennis John M, Florez Jose C, Gloyn Anna L, Gomez Maria F, Gottlieb Peter A, Greeley Siri Atma W, Griffin Kurt, Hattersley Andrew T, Hirsch Irl B, Hivert Marie-France, Hood Korey K, Josefson Jami L, Kwak Soo Heon, Laffel Lori M, Lim Siew S, Loos Ruth J F, Ma Ronald C W, Mathieu Chantal, Mathioudakis Nestoras, Meigs James B, Misra Shivani, Mohan Viswanathan, Murphy Rinki, Oram Richard, Owen Katharine R, Ozanne Susan E, Pearson Ewan R, Perng Wei, Pollin Toni I, Pop-Busui Rodica, Pratley Richard E, Redman Leanne M, Redondo Maria J, Reynolds Rebecca M, Semple Robert K, Sherr Jennifer L, Sims Emily K, Sweeting Arianne, Tuomi Tiinamaija, Udler Miriam S, Vesco Kimberly K, Vilsbøll Tina, Wagner Robert, Rich Stephen S, Franks Paul W
СтатьяОбзорПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАConsensus StatementПеревод в очереди
Аннотация
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
Для цитирования: Tobias Deirdre K, Merino Jordi, Ahmad Abrar, Aiken Catherine, Benham Jamie L, Bodhini Dhanasekaran, Clark Amy L, Colclough Kevin, Corcoy Rosa, Cromer Sara J, Duan Daisy, Felton Jamie L, Francis Ellen C, Gillard Pieter, Gingras Véronique, Gaillard Romy, Haider Eram, Hughes Alice, Ikle Jennifer M, Jacobsen Laura M, Kahkoska Anna R, Kettunen Jarno L T, Kreienkamp Raymond J, Lim Lee-Ling, Männistö Jonna M E, Massey Robert, Mclennan Niamh-Maire, Miller Rachel G, Morieri Mario Luca, Most Jasper, Naylor Rochelle N, Ozkan Bige, Patel Kashyap Amratlal, Pilla Scott J, Prystupa Katsiaryna, Raghavan Sridharan, Rooney Mary R, Schön Martin, Semnani-Azad Zhila, Sevilla-Gonzalez Magdalena, Svalastoga Pernille, Takele Wubet Worku, Tam Claudia Ha-Ting, Thuesen Anne Cathrine B, Tosur Mustafa, Wallace Amelia S, Wang Caroline C, Wong Jessie J, Yamamoto Jennifer M, Young Katherine, Amouyal Chloé, Andersen Mette K, Bonham Maxine P, Chen Mingling, Cheng Feifei, Chikowore Tinashe, Chivers Sian C, Clemmensen Christoffer, Dabelea Dana, Dawed Adem Y, Deutsch Aaron J, Dickens Laura T, DiMeglio Linda A, Dudenhöffer-Pfeifer Monika, Evans-Molina Carmella, Fernández-Balsells María Mercè, Fitipaldi Hugo, Fitzpatrick Stephanie L, Gitelman Stephen E, Goodarzi Mark O, Grieger Jessica A, Guasch-Ferré Marta, Habibi Nahal, Hansen Torben, Huang Chuiguo, Harris-Kawano Arianna, Ismail Heba M, Hoag Benjamin, Johnson Randi K, Jones Angus G, Koivula Robert W, Leong Aaron, Leung Gloria K W, Libman Ingrid M, Liu Kai, Long S Alice, Lowe William L, Morton Robert W, Motala Ayesha A, Onengut-Gumuscu Suna, Pankow James S, Pathirana Maleesa, Pazmino Sofia, Perez Dianna, Petrie John R, Powe Camille E, Quinteros Alejandra, Jain Rashmi, Ray Debashree, Ried-Larsen Mathias, Saeed Zeb, Santhakumar Vanessa, Kanbour Sarah, Sarkar Sudipa, Monaco Gabriela S F, Scholtens Denise M, Selvin Elizabeth, Sheu Wayne Huey-Herng, Speake Cate, Stanislawski Maggie A, Steenackers Nele, Steck Andrea K, Stefan Norbert, Støy Julie, Taylor Rachael, Tye Sok Cin, Ukke Gebresilasea Gendisha, Urazbayeva Marzhan, Van der Schueren Bart, Vatier Camille, Wentworth John M, Hannah Wesley, White Sara L, Yu Gechang, Zhang Yingchai, Zhou Shao J, Beltrand Jacques, Polak Michel, Aukrust Ingvild, de Franco Elisa, Flanagan Sarah E, Maloney Kristin A, McGovern Andrew, Molnes Janne, Nakabuye Mariam, Njølstad Pål Rasmus, Pomares-Millan Hugo, Provenzano Michele, Saint-Martin Cécile, Zhang Cuilin, Zhu Yeyi, Auh Sungyoung, de Souza Russell, Fawcett Andrea J, Gruber Chandra, Mekonnen Eskedar Getie, Mixter Emily, Sherifali Diana, Eckel Robert H, Nolan John J, Philipson Louis H, Brown Rebecca J, Billings Liana K, Boyle Kristen, Costacou Tina, Dennis John M, Florez Jose C, Gloyn Anna L, Gomez Maria F, Gottlieb Peter A, Greeley Siri Atma W, Griffin Kurt, Hattersley Andrew T, Hirsch Irl B, Hivert Marie-France, Hood Korey K, Josefson Jami L, Kwak Soo Heon, Laffel Lori M, Lim Siew S, Loos Ruth J F, Ma Ronald C W, Mathieu Chantal, Mathioudakis Nestoras, Meigs James B, Misra Shivani, Mohan Viswanathan, Murphy Rinki, Oram Richard, Owen Katharine R, Ozanne Susan E, Pearson Ewan R, Perng Wei, Pollin Toni I, Pop-Busui Rodica, Pratley Richard E, Redman Leanne M, Redondo Maria J, Reynolds Rebecca M, Semple Robert K, Sherr Jennifer L, Sims Emily K, Sweeting Arianne, Tuomi Tiinamaija, Udler Miriam S, Vesco Kimberly K, Vilsbøll Tina, Wagner Robert, Rich Stephen S, Franks Paul W. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.. Nature medicine. 2023. DOI: 10.1038/s41591-023-02502-5.
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