Медицинская библиотека · Science (New York, N.Y.) · 2019
Somatic evolution and global expansion of an ancient transmissible cancer lineage.
Baez-Ortega Adrian, Gori Kevin, Strakova Andrea, Allen Janice L, Allum Karen M, Bansse-Issa Leontine, Bhutia Thinlay N, Bisson Jocelyn L, Briceño Cristóbal, Castillo Domracheva Artemio, Corrigan Anne M, Cran Hugh R, Crawford Jane T, Davis Eric, de Castro Karina F, B de Nardi Andrigo, de Vos Anna P, Delgadillo Keenan Laura, Donelan Edward M, Espinoza Huerta Adela R, Faramade Ibikunle A, Fazil Mohammed, Fotopoulou Eleni, Fruean Skye N, Gallardo-Arrieta Fanny, Glebova Olga, Gouletsou Pagona G, Häfelin Manrique Rodrigo F, Henriques Joaquim J G P, Horta Rodrigo S, Ignatenko Natalia, Kane Yaghouba, King Cathy, Koenig Debbie, Krupa Ada, Kruzeniski Steven J, Kwon Young-Mi, Lanza-Perea Marta, Lazyan Mihran, Lopez Quintana Adriana M, Losfelt Thibault, Marino Gabriele, Martínez Castañeda Simón, Martínez-López Mayra F, Meyer Michael, Migneco Edward J, Nakanwagi Berna, Neal Karter B, Neunzig Winifred, Ní Leathlobhair Máire, Nixon Sally J, Ortega-Pacheco Antonio, Pedraza-Ordoñez Francisco, Peleteiro Maria C, Polak Katherine, Pye Ruth J, Reece John F, Rojas Gutierrez Jose, Sadia Haleema, Schmeling Sheila K, Shamanova Olga, Sherlock Alan G, Stammnitz Maximilian, Steenland-Smit Audrey E, Svitich Alla, Tapia Martínez Lester J, Thoya Ngoka Ismail, Torres Cristian G, Tudor Elizabeth M, van der Wel Mirjam G, Viţălaru Bogdan A, Vural Sevil A, Walkinton Oliver, Wang Jinhong, Wehrle-Martinez Alvaro S, Widdowson Sophie A E, Stratton Michael R, Alexandrov Ludmil B, Martincorena Iñigo, Murchison Elizabeth P
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Аннотация
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.
Для цитирования: Baez-Ortega Adrian, Gori Kevin, Strakova Andrea, Allen Janice L, Allum Karen M, Bansse-Issa Leontine, Bhutia Thinlay N, Bisson Jocelyn L, Briceño Cristóbal, Castillo Domracheva Artemio, Corrigan Anne M, Cran Hugh R, Crawford Jane T, Davis Eric, de Castro Karina F, B de Nardi Andrigo, de Vos Anna P, Delgadillo Keenan Laura, Donelan Edward M, Espinoza Huerta Adela R, Faramade Ibikunle A, Fazil Mohammed, Fotopoulou Eleni, Fruean Skye N, Gallardo-Arrieta Fanny, Glebova Olga, Gouletsou Pagona G, Häfelin Manrique Rodrigo F, Henriques Joaquim J G P, Horta Rodrigo S, Ignatenko Natalia, Kane Yaghouba, King Cathy, Koenig Debbie, Krupa Ada, Kruzeniski Steven J, Kwon Young-Mi, Lanza-Perea Marta, Lazyan Mihran, Lopez Quintana Adriana M, Losfelt Thibault, Marino Gabriele, Martínez Castañeda Simón, Martínez-López Mayra F, Meyer Michael, Migneco Edward J, Nakanwagi Berna, Neal Karter B, Neunzig Winifred, Ní Leathlobhair Máire, Nixon Sally J, Ortega-Pacheco Antonio, Pedraza-Ordoñez Francisco, Peleteiro Maria C, Polak Katherine, Pye Ruth J, Reece John F, Rojas Gutierrez Jose, Sadia Haleema, Schmeling Sheila K, Shamanova Olga, Sherlock Alan G, Stammnitz Maximilian, Steenland-Smit Audrey E, Svitich Alla, Tapia Martínez Lester J, Thoya Ngoka Ismail, Torres Cristian G, Tudor Elizabeth M, van der Wel Mirjam G, Viţălaru Bogdan A, Vural Sevil A, Walkinton Oliver, Wang Jinhong, Wehrle-Martinez Alvaro S, Widdowson Sophie A E, Stratton Michael R, Alexandrov Ludmil B, Martincorena Iñigo, Murchison Elizabeth P. Somatic evolution and global expansion of an ancient transmissible cancer lineage.. Science (New York, N.Y.). 2019. DOI: 10.1126/science.aau9923.
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