Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2012
Limitations of Chromogranin A in clinical practice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Marotta Vincenzo, Nuzzo Vincenzo, Ferrara Teresa, Zuccoli Alfonso, Masone Milena, Nocerino Lorenzo, Del Prete Michela, Marciello Francesca, Ramundo Valeria, Lombardi Gaetano, Vitale Mario, Colao Annamaria, Faggiano Antongiulio
Аннотация
CONTEXT: Usefulness of circulating Chromogranin A (CgA) for the diagnosis of neuroendocrine tumors (NEN) is controversial. The aim of the present study was to assess the actual role of this marker as diagnostic tool.
METHODS: Serum blood samples were obtained from 42 subjects affected with NEN, 120 subjects affected with non-endocrine neoplasias (non-NEN) and 100 non-neoplastic subjects affected with benign nodular goitre (NNG). Determination of CgA was performed by means of immunoradiometric assay.
RESULTS: The CgA levels among NEN-patients were not significantly different from NNG and non-NEN subjects. The Receiver operating characteristic (ROC) curves analysis failed to identify a feasible cut-off value for the differential diagnosis between NEN and the other conditions.
CONCLUSION: Serum CgA is not helpful for the first-line diagnosis of NEN.
METHODS: Serum blood samples were obtained from 42 subjects affected with NEN, 120 subjects affected with non-endocrine neoplasias (non-NEN) and 100 non-neoplastic subjects affected with benign nodular goitre (NNG). Determination of CgA was performed by means of immunoradiometric assay.
RESULTS: The CgA levels among NEN-patients were not significantly different from NNG and non-NEN subjects. The Receiver operating characteristic (ROC) curves analysis failed to identify a feasible cut-off value for the differential diagnosis between NEN and the other conditions.
CONCLUSION: Serum CgA is not helpful for the first-line diagnosis of NEN.