[The effect of diabetes mellitus on the renal prostanoid system and on the arterial pressure level in spontaneously hypertensive rats].

The authors studied the effect of diabetes mellitus on the renal prostanoid (PN) system in rats with spontaneous hypertension. Marked changes of renal PN excretion, biosynthesis, and metabolism were revealed. The absence of signs of diabetic nephropathy in rats with hereditary determined hypertension may be attributed to increased production of prostaglandin E and prostacyclin. These PN augment the renal blood flow, prevent sodium retention in the organism, and inhibit the progress of arterial hypertension which is one of the signs characteristic of diabetic nephropathy.