Effect of chlorpromazine hydrochloride on the formation of micronuclei in the bone marrow of mice exposed to gamma radiation.

The frequency of micronuclei was determined in the bone marrow of female BALB/c mice treated with various doses of chlorpromazine hydrochloride (CPZ) before exposure to 4.0 Gy of gamma radiation at 24 h post-exposure. In animals treated with CPZ alone, the frequency of micronuclei increased with the increase in drug dose. A similar pattern was observed when the mice were exposed to 4.0 Gy radiation after CPZ treatment. The dose response curves thus obtained for the CPZ treated and CPZ + irradiated groups were linear quadratic.