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DOI 10.1093/rheumatology/keaf613

Медицинская библиотека · Rheumatology (Oxford, England) · 2026

Risk of major organ involvement in Behçet's patients with mucocutaneous onset: data from the AIDA Network Registry.

Vitale Antonio, Gavioli Francesco, Caggiano Valeria, Sbalchiero Jessica, Lopalco Giuseppe, Ragab Gaafar, Guerriero Silvana, AlMaglouth Ibrahim, Tufan Abdurrahman, Giacomelli Roberto, Direskeneli Haner, Ruscitti Piero, Hatemi Gülen, Carubbi Francesco, Batu Ezgi Deniz, Ozen Seza, Sota Jurgen, Giardini Henrique Ayres Mayrink, Frassi Micol, Sfikakis Petros P, Iannone Florenzo, Morrone Maria, Ghanema Mahmoud, Saad Moustafa Ali, Dammacco Rosanna, Kucuk Hamit, Kardas Riza Can, Cakir Ibrahim Yahya, Navarini Luca, Alibaz Öner Fatma, Sevik Gizem, Gentile Martina, Karakoc Alican, Alunno Alessia, Ercan Emreol Hulya, Crisafulli Francesca, Fragoulis George, Ciccia Francesco, Thabet Maissa, Bugatti Serena, Milanesi Alessandra, Chimenti Maria Sole, Monosi Benedetta, Piga Matteo, Floris Alberto, Hinojosa-Azaola Andrea, Guaracha-Basañez Guillermo Arturo, Chighizola Cecilia Beatrice, Hernández-Rodríguez José, Cattalini Marco, Govoni Marcello, Viapiana Ombretta, Civino Adele, Opris-Belinski Daniela, Gaggiano Carla, Talarico Rosaria, Giardina Annarita, Emmi Giacomo, Sarzi Puttini Piercarlo, Maggio Maria Cristina, Parronchi Paola, Portincasa Piero, de-la-Torre Alejandra, Aguilar-Barrera Blanca, Gentileschi Stefano, Mauro Angela, Sebastiani Gian Domenico, Olivieri Alma Nunzia, Şahin Ali, Rigante Donato, Bilgin Emre, Del Giudice Emanuela, Breda Luciana, De Paulis Amato, Lo Gullo Alberto, Erten Şükran, Tharwat Samar, Fotis Lampros, Maier Armin, Insalaco Antonella, Karamanakos Anastasios, Conforti Alessandro, Soysal Gündüz Özgül, Moshrif Abdelhfeez, Li Gobbi Francesca, Balistreri Alberto, Bartoloni Elena, Barone Patrizia, Guiducci Serena, Gonzáles-García Andrés, Hernanz Rodriguez Inés, Conti Giovanni, Iagnocco Annamaria, Önen Fatos, Al-Mayouf Sulaiman M, Ucar Didar, Frediani Bruno, Fabiani Claudia, Cantarini Luca, from the International AIDA (AutoInflammatory Diseases Alliance) Network

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Аннотация

OBJECTIVES

The progression of Behçet's disease (BD) from a mucocutaneous-limited form to major organ involvement (MOI) represents a significant challenge. This study aims to identify patients without MOI at BD onset who are at increased risk of developing MOI in later stages.

METHODS

Patients' data were drawn from the International AutoInflammatory Disease Alliance (AIDA) Network registry dedicated to BD.

RESULTS

A total of 328 patients with exclusively mucocutaneous manifestations at BD onset were enrolled. Of these, 82 patients (25%) developed MOI over the entire follow-up period. Patients with minor oral aphthosis and no major oral aphthosis exhibited a reduced risk of developing MOI, with an odds ratio (OR) of 0.41 [95% confidence interval (95%CI): 0.22-0.79, P = 0.008]. Conversely, patients with both major and minor oral aphthosis had a significantly higher risk of developing MOI, with an OR of 12.76 (95%CI: 1.44-113, P = 0.02). Moreover, the development of MOI was associated with major oral aphthosis plus genital aphthosis (OR: 2.49, 95%CI: 1.1-5.6, P = 0.03), major oral aphthosis plus pseudofolliculitis (OR: 2.9, 95%CI: 1.15-7.4, P = 0.02) and major oral aphthosis plus both genital aphthosis and pseudofolliculitis (OR: 3.73, 95%CI: 1.22-11.4, P = 0.02). A positive family history for BD was associated with MOI (OR: 2.85, 95%CI: 1.08-7.58, P = 0.03).

CONCLUSION

A positive family history and the presence of major oral aphthosis combined with minor oral aphthosis, genital aphthosis or pseudofolliculitis are associated with MOI development in patients with mucocutaneous BD at onset.

Для цитирования: Vitale Antonio, Gavioli Francesco, Caggiano Valeria, Sbalchiero Jessica, Lopalco Giuseppe, Ragab Gaafar, Guerriero Silvana, AlMaglouth Ibrahim, Tufan Abdurrahman, Giacomelli Roberto, Direskeneli Haner, Ruscitti Piero, Hatemi Gülen, Carubbi Francesco, Batu Ezgi Deniz, Ozen Seza, Sota Jurgen, Giardini Henrique Ayres Mayrink, Frassi Micol, Sfikakis Petros P, Iannone Florenzo, Morrone Maria, Ghanema Mahmoud, Saad Moustafa Ali, Dammacco Rosanna, Kucuk Hamit, Kardas Riza Can, Cakir Ibrahim Yahya, Navarini Luca, Alibaz Öner Fatma, Sevik Gizem, Gentile Martina, Karakoc Alican, Alunno Alessia, Ercan Emreol Hulya, Crisafulli Francesca, Fragoulis George, Ciccia Francesco, Thabet Maissa, Bugatti Serena, Milanesi Alessandra, Chimenti Maria Sole, Monosi Benedetta, Piga Matteo, Floris Alberto, Hinojosa-Azaola Andrea, Guaracha-Basañez Guillermo Arturo, Chighizola Cecilia Beatrice, Hernández-Rodríguez José, Cattalini Marco, Govoni Marcello, Viapiana Ombretta, Civino Adele, Opris-Belinski Daniela, Gaggiano Carla, Talarico Rosaria, Giardina Annarita, Emmi Giacomo, Sarzi Puttini Piercarlo, Maggio Maria Cristina, Parronchi Paola, Portincasa Piero, de-la-Torre Alejandra, Aguilar-Barrera Blanca, Gentileschi Stefano, Mauro Angela, Sebastiani Gian Domenico, Olivieri Alma Nunzia, Şahin Ali, Rigante Donato, Bilgin Emre, Del Giudice Emanuela, Breda Luciana, De Paulis Amato, Lo Gullo Alberto, Erten Şükran, Tharwat Samar, Fotis Lampros, Maier Armin, Insalaco Antonella, Karamanakos Anastasios, Conforti Alessandro, Soysal Gündüz Özgül, Moshrif Abdelhfeez, Li Gobbi Francesca, Balistreri Alberto, Bartoloni Elena, Barone Patrizia, Guiducci Serena, Gonzáles-García Andrés, Hernanz Rodriguez Inés, Conti Giovanni, Iagnocco Annamaria, Önen Fatos, Al-Mayouf Sulaiman M, Ucar Didar, Frediani Bruno, Fabiani Claudia, Cantarini Luca, from the International AIDA (AutoInflammatory Diseases Alliance) Network. Risk of major organ involvement in Behçet's patients with mucocutaneous onset: data from the AIDA Network Registry.. Rheumatology (Oxford, England). 2026. DOI: 10.1093/rheumatology/keaf613.
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