The association between vitamin D status and recurrent wheezing.

OBJECTIVE

To investigate association between vitamin D status and recurrent wheezing in infants.

METHODS

Thirty infants with recurrent wheezing and 45 healthy, similar aged infants without any history of acute or chronic illness were included in the study. The clinical features of infants were recorded and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. Data analysis was performed using SPSS 13 package program.

RESULTS

The mean value of 25 (OH) D vitamin levels were 22.1 ± 8.9 IU/L and 18.8 ± 11 IU/L for the control and recurrent attack group respectively. Seventy-three percent of subjects with recurrent wheezing had vitamin D levels in the deficient range (<20 ng/ml) and 48.9 % had vitamin D levels under < 20 ng/ml in the control group. The percentage of insufficient vitamin D levels (<30 ng/ml) were 90 and 77.8 for the patient and control group respectively. Eight patients had extremely deficient vitamin D (<10 ng/ml) levels. There was no statistical significance between the groups in terms of the distribution of 25 (OH)D level.

CONCLUSIONS

The present study did not demonstrate significant association between vitamin D status and recurrent wheezing in the infants.