Scientific reports · 2013
Aetiologies of central nervous system infections in adults in Kathmandu, Nepal: a prospective hospital-based study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Giri Abhishek, Arjyal Amit, Koirala Samir, Karkey Abhilasha, Dongol Sabina, Thapa Sudeep Dhoj, Shilpakar Olita, Shrestha Rishav, van Tan Le, Thi Thuy Chinh Bkrong Nguyen, Krishna K C Radheshyam, Pathak Kamal Raj, Shakya Mila, Farrar Jeremy, Van Doorn H Rogier, Basnyat Buddha
Аннотация
We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients were recruited for the study and the etiological diagnosis was established in 38% (n = 33). The bacterial pathogens identified were Neisseria meningitidis (n = 6); Streptococcus pneumoniae (n = 5) and Staphylococcus aureus (n = 2) in 13/87(14%). Enteroviruses were found in 12/87 (13%); Herpes Simplex virus (HSV) in 2/87(2%). IgM against Japanese encephalitis virus (JEV) was detected in the CSF of 11/73 (15%) tested samples. This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting.