Медицинская библиотека · Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology · 2015

[Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats].

Wang Zhi-wang, Li Rong-ke, Lin Xing-yao, Ren Yuan, Liu Xue-feng, Cheng Xiao-li, Wang Rui-qiong

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Аннотация

OBJECTIVE

To study the effects of Volatile Oil of Radix Angelicae Sinensis (VOA) on experimental asthma in rat model based on abnormal immune functions of Treg cells.

METHODS

After grouping, the asthmatic rats were developed through injecting OVA and AI(OH)3 for sensitization and then administering OVA aerosol for challenge, and the respiratory functions, asthmatic behaviors, IL-10 levels in bronchoalveolar lavage fluid (BALF) (ELISA) and Foxp3 expression (immunohistochemistry) in lung of asthmatic rats were observed.

RESULTS

VOA at the doses of 40-160 mg/kg could improve the respiratory functions and the asthmatic behaviors, and upgrade IL-10 levels in BALF and Foxp3 expression in lung of asthmatic rats.

CONCLUSION

VOA has some effects of anti-asthma and one of the mechanisms is to improving the lower immune functions of Treg cells.

Для цитирования: Wang Zhi-wang, Li Rong-ke, Lin Xing-yao, Ren Yuan, Liu Xue-feng, Cheng Xiao-li, Wang Rui-qiong. [Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats].. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2015.

Предметные рубрики MeSH

Angelica sinensis Animals Asthma Bronchoalveolar Lavage Fluid Disease Models, Animal Forkhead Transcription Factors Interleukin-10 Lung Oils, Volatile Plant Oils Rats T-Lymphocytes, Regulatory

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