Nature communications · 2020
Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wang Xiang-Ming, Lu Yang, Song Yi-Meng, Dong Jun, Li Ruo-Yan, Wang Guo-Liang, Wang Xu, Zhang Shu-Dong, Dong Zhou-Huan, Lu Min, Wang Shi-Yu, Ge Li-Yuan, Luo Guang-Da, Ma Run-Zhuo, George Rozen Steve, Bai Fan, Wu Di, Ma Lu-Lin
Аннотация
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing on 110 normal-tumor pairs and 42 normal-tumor-thrombus triples, and transcriptome sequencing on 61 tumor-normal pairs and 30 primary-thrombus pairs from 152 Chinese patients with ccRCC. Our analysis reveals that a mutational signature associated with aristolochic acid (AA) exposure is widespread in Chinese ccRCC. Tumors from patients with ccRCC-TT show a higher mutational burden and genomic instability; in addition, mutations in BAP1 and SETD2 are highly enriched in patients with ccRCC-TT. Moreover, patients with/without TT show distinct molecular characteristics. We reported the integrative genomic sequencing of Chinese ccRCC and identified the features associated with tumor thrombus, which may facilitate ccRCC diagnosis, prognosis and treatment.