Медицинская библиотека · Langenbeck's archives of surgery · 2025

Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study.

Neves-Marques Claudia, Abulazayem Mohamed, Wong Geoffrey Yuet Mun, Maldonado Ricardo David, Viswanath Yirupaiahgari, Boddy Alex, Donohoe Claire, Scarano Juan Pablo, Martinino Alessandro, Aamery Amaar, Abdulkhakimov Nuriddin, Abuobaida Essam Eldien, Aday Ulaş, Al-Shami Khayry, Alhajami Faris, Almeida Ana, Almoshantaf Mohammad Badr, Ahmed Hassan, Andrada Martín, Anwer Abdul Wahid, Awad Ahmed K, Baili Efstratia, Baraket Oussama, Barbosa José, Baker Cara, Bakri Ashraf, Boras Zdenko, Caiado André, Cayirci Can, Calini Giacomo, Cianci Pasquale, Cinal Esin, Chouliaras Christos, Colak Elif, Correia Maria Teresa, Costeira Beatriz, Davletshina Viktoria, D'Acapito Fabrizio, Donmez Turgut, Drozdov Evgeniy, Ercolani Giorgio, Erdene Sarnai, Erginöz Ergin, Ferreira Samantha Rocha, Fragoso Marta, Framarini Massimo, Galandarova Aysuna, Genser Laurent, Gorohov Ilya, Grosek Jan, Guerrero Silvia, Hasırcı Ismail, Ibrahimli Arturan, Ithurralde-Argerich Javier, Karabulut Mehmet, Kinoshita Takahiro, Khalid Ibtissam Bin, Khan Khurram, Khattak Shahid, Khomyakov Vladimir, Krawczyk Wiktor, Khamees Almu'atasim, Kostrygin Alexander, Košir Jurij, Lorenc Zbigniew, Milhomem Jorge, Marom Gadi, Melo Ana, Menasria Abdelkader, Meric Serhat, Mulita Francesk, Muratore Andrea, Omarov Taryel, Palomba Giuseppe, Paul Negine, Pathak Akshant, Pavone Giovanna, Pavlov Rostislav, Pinillla Raul, Rasheed Omeed, Remini Anouar, Ryabov Andrey, Samadov Elgun, Samarasam Inian, Sandag Erdene, Santos Jorge, Sanchez Elio, Saroglu Azize, Schizas Dimitrios, Serralheiro Pedro Azevedo, Simsek Oguzhan, Sobolev Dmitry, Souadka Amine, de Sousa José Vieira, Sousa Fabiana, Suer Muhammed, Surendran Suraj, Syllaios Athanasios, Syed Aamir Ali, Terajima Daiki, Tokocin Merve, Triantafyllou Tania, Uludağ Server, Uprak Tevfik, Vaz Susan, Vecchiato Massimo, Verras Georgios Ioannis, Veroux Massimiliano, Voon Kelvin, Vovin Kirill, Yacob Myla, Walędziak Maciej, Zacharenko Alexander, Zahara Fatima Tu, Singhal Rishi, Mahawar Kamal, HOLD Study Collaborative Group

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Аннотация

BACKGROUND

Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors.

METHODS

We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome.

RESULTS

380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19-94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality.

CONCLUSION

Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes.

Для цитирования: Neves-Marques Claudia, Abulazayem Mohamed, Wong Geoffrey Yuet Mun, Maldonado Ricardo David, Viswanath Yirupaiahgari, Boddy Alex, Donohoe Claire, Scarano Juan Pablo, Martinino Alessandro, Aamery Amaar, Abdulkhakimov Nuriddin, Abuobaida Essam Eldien, Aday Ulaş, Al-Shami Khayry, Alhajami Faris, Almeida Ana, Almoshantaf Mohammad Badr, Ahmed Hassan, Andrada Martín, Anwer Abdul Wahid, Awad Ahmed K, Baili Efstratia, Baraket Oussama, Barbosa José, Baker Cara, Bakri Ashraf, Boras Zdenko, Caiado André, Cayirci Can, Calini Giacomo, Cianci Pasquale, Cinal Esin, Chouliaras Christos, Colak Elif, Correia Maria Teresa, Costeira Beatriz, Davletshina Viktoria, D'Acapito Fabrizio, Donmez Turgut, Drozdov Evgeniy, Ercolani Giorgio, Erdene Sarnai, Erginöz Ergin, Ferreira Samantha Rocha, Fragoso Marta, Framarini Massimo, Galandarova Aysuna, Genser Laurent, Gorohov Ilya, Grosek Jan, Guerrero Silvia, Hasırcı Ismail, Ibrahimli Arturan, Ithurralde-Argerich Javier, Karabulut Mehmet, Kinoshita Takahiro, Khalid Ibtissam Bin, Khan Khurram, Khattak Shahid, Khomyakov Vladimir, Krawczyk Wiktor, Khamees Almu'atasim, Kostrygin Alexander, Košir Jurij, Lorenc Zbigniew, Milhomem Jorge, Marom Gadi, Melo Ana, Menasria Abdelkader, Meric Serhat, Mulita Francesk, Muratore Andrea, Omarov Taryel, Palomba Giuseppe, Paul Negine, Pathak Akshant, Pavone Giovanna, Pavlov Rostislav, Pinillla Raul, Rasheed Omeed, Remini Anouar, Ryabov Andrey, Samadov Elgun, Samarasam Inian, Sandag Erdene, Santos Jorge, Sanchez Elio, Saroglu Azize, Schizas Dimitrios, Serralheiro Pedro Azevedo, Simsek Oguzhan, Sobolev Dmitry, Souadka Amine, de Sousa José Vieira, Sousa Fabiana, Suer Muhammed, Surendran Suraj, Syllaios Athanasios, Syed Aamir Ali, Terajima Daiki, Tokocin Merve, Triantafyllou Tania, Uludağ Server, Uprak Tevfik, Vaz Susan, Vecchiato Massimo, Verras Georgios Ioannis, Veroux Massimiliano, Voon Kelvin, Vovin Kirill, Yacob Myla, Walędziak Maciej, Zacharenko Alexander, Zahara Fatima Tu, Singhal Rishi, Mahawar Kamal, HOLD Study Collaborative Group. Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study.. Langenbeck's archives of surgery. 2025. DOI: 10.1007/s00423-025-03890-7.

Предметные рубрики MeSH

Humans Stomach Neoplasms Male Female Aged Prospective Studies Middle Aged Elective Surgical Procedures Aged, 80 and over Postoperative Complications Gastrectomy Adult Young Adult Morbidity Risk Factors

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