Optical resolution of glycerin sulfides and glycerin selenides on the chiral stationary phase of cellulose-tris(3, 5-dimethylphenylcarbamate).

Cellulose-tris(3,5-dimethylphenylcarbamate) was prepared after a reported method and was coated onto an aminopropylated mesopore spherical silica gel. The final product was used as a chiral stationary phase of high performance liquid chromatography for the enantioseparation of a series of glycerin sulfides and glycerin selenides. Mixtures of hexane and 2-propanol were used as mobile phases. The effects of 2-propanol concentration in the mobile phase on the retention and resolution were investigated. Some enantiomers of the glycerin monosulfides and monoselenides could be separated satisfactorily, but none of the disulfides could be separated. The structural features of the solutes that influence chiral separation were discussed. Copyright 1999 Wiley-Liss, Inc.