In vivo (Athens, Greece) · 2006
Combined mucormycosis and Aspergillosis of the rhinocerebral region.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alfano Carmine, Chiummariello Stefano, Dessy Luca A, Bistoni Giovanni, Scuderi Nicolò
Аннотация
BACKGROUND: Opportunistic fungal infections are rare, life-threatening conditions and are a major cause of morbidity and mortality in immunocompromised hosts. Our experience in the management of a case of combined mucormycosis and aspergillosis of the rhinocerebral region is presented.
PATIENTS AND METHODS: The infection developed a few weeks after tooth extraction, massively involving facial structures. After diagnosis, the patient underwent prolonged combined systemic antifungal treatment. Once the local and general conditions had stabilized, an extensive surgical debridement was performed, followed by reconstruction with a pedicled myocutaneous flap.
RESULTS: This approach was curative with patient survival after 16 months.
CONCLUSION: Early diagnosis, early anti-fungal treatment and early stabilization of the patients' general condition are fundamental for patient survival. Surgery is necessary for fungal eradication, but must be performed according to the above conditions. Pedicled muscle flaps are considered the first reconstruction choice because of their excellent blood perfusion and resistance to fungal invasion.
PATIENTS AND METHODS: The infection developed a few weeks after tooth extraction, massively involving facial structures. After diagnosis, the patient underwent prolonged combined systemic antifungal treatment. Once the local and general conditions had stabilized, an extensive surgical debridement was performed, followed by reconstruction with a pedicled myocutaneous flap.
RESULTS: This approach was curative with patient survival after 16 months.
CONCLUSION: Early diagnosis, early anti-fungal treatment and early stabilization of the patients' general condition are fundamental for patient survival. Surgery is necessary for fungal eradication, but must be performed according to the above conditions. Pedicled muscle flaps are considered the first reconstruction choice because of their excellent blood perfusion and resistance to fungal invasion.
Предметные рубрики MeSH
Amphotericin BAntifungal AgentsAspergillosisAspergillus fumigatusBrain AbscessCaspofunginCombined Modality TherapyDebridementDrug Therapy, CombinationEchinocandinsFemaleHumansLipopeptidesMiddle AgedMucoralesMucormycosisOtorhinolaryngologic Surgical ProceduresParanasal Sinus DiseasesPeptides, CyclicPyrimidinesPlastic Surgery ProceduresTooth ExtractionTreatment OutcomeTriazolesVoriconazole