The use of methyl cyanoacrylate (MCA) for female sterilization. Program for Applied Research on Fertility Regulation Northwestern University Medical School Chicago, Illinois.

The results of studies are presented that evaluated one or two intrauterine applications of MCA for permanent sterilization. The studies were conducted under several different protocols and included 652 women. Complications of the procedures were infrequent. There were 3 suspected uterine perforations, but surgical treatment was not required. Based on hysterosalpingogram (HSG) readings, bilateral tubal closure was obtained in 70.2% of the women after one MCA application and in 90.3% of the women after two MCA applications. The use of a uterine lavage before MCA application, the time between the first and second MCA application and the use of radio-opaque or non-radio-opaque MCA did not significantly (p less than 0.05) alter the bilateral tubal closure rates.