Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials · 2007
[Experimental research about the effect of Rehmannia glutinosa on the drug effect fingerprints of the rabbit's blood serum of Yin deficiency and heat flourishing syndrome].
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Feng Zhi-yi, Cui Ying, Ding Gang, Zhang Bing
Аннотация
OBJECTIVE: To study about the effect of Rehmannia glutinosa Libosch on the drug effect fingerprints of the rabbit's blood serum of yin deficiency and heat flourishing syndrome.
METHODS: The infusion of furosemide and escherichia coli endotoxin were used to replicate rabbit' s yin deficiency and heat flourishing syndrome animal model; high performance liquid chromatography gradient elution was adopped to study the change of the rabbit serum drug effect fingerprint in copying between before and after model-making and administration.
RESULTS: Rehmannia glutinosa Libosch mainly affected metabolism level of the inner substance with the function of nourishing yin clearing heat.
CONCLUSION: The serum HPLC fingerprint established is capable to reflect the function of nourishing yin clearing heat of Rehmannia glutinosa Libosch; the further study on its drug effect fingerprint will help to clarify its activity and metabolism of action.
METHODS: The infusion of furosemide and escherichia coli endotoxin were used to replicate rabbit' s yin deficiency and heat flourishing syndrome animal model; high performance liquid chromatography gradient elution was adopped to study the change of the rabbit serum drug effect fingerprint in copying between before and after model-making and administration.
RESULTS: Rehmannia glutinosa Libosch mainly affected metabolism level of the inner substance with the function of nourishing yin clearing heat.
CONCLUSION: The serum HPLC fingerprint established is capable to reflect the function of nourishing yin clearing heat of Rehmannia glutinosa Libosch; the further study on its drug effect fingerprint will help to clarify its activity and metabolism of action.