Long-term outcomes and prognosis of mixed cryoglobulinaemia: a European multicentre study of 1294 patients.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Saadoun David, Cacoub Patrice, Retamozo Soledad, Sebastiani Marco, Vacchi Caterina, Casato Milvia, Visentini Marcella, Brito-Zerón Pilar, Flores-Chávez Alejandra, Praprotnik Sonja, Ismail Gener, Quartuccio Luca, Nocturne Gaetane, Szanto Antonia, Maalouf Georgina, Bartoli Alessandra, Ghillani-Dalbin Pascale, Torre Ricardo Gómez de la, Pertusa Mataix Roberto, Conde Andrea Núñez, Bartoloni Elena, León Laura, Mercadé-Torras Joan Maria, Sebastian Agata, Carubbi Francesco, Atzeni Fabiola, Rial-Villavecchia Aborá, Mariette Xavier, Jurcut Ciprian, Vieira Matheus, Chevret Sylvie, Ramos-Casals Manuel
Аннотация
METHODS: A European multicentre cohort study (EuroCryo) of 1294 patients presenting with all-cause CryoVas.
RESULTS: The main aetiology for CryoVas was Hepatitis C Virus ( HCV) with 469 (36%) cases, followed by essential forms (n = 344, 26%) and autoimmune conditions (n = 302, 23%), with Sjögren's disease being the most common (n = 268, 21%). Over a median follow-up of 2.8 years, a total of 558 CryoVas patients experienced 661 severe events, notably 221 relapses, 52 severe infections and 45 lymphomas. The multivariable model for event-free survival retained a post-2014 diagnosis, male sex, older age, low C4 levels, positive Rheumatoid Factor and higher baseline creatinine levels as poor prognostic factors; HCV aetiology was protective. Factors associated with the occurrence of lymphoma were a post-2014 diagnosis, autoimmune aetiology, fever, fatigue and low C4 levels.
CONCLUSION: HCV was for long considered a poor prognosis factor in CryoVas, and now those secondary to autoimmune conditions seem to evolve with a more severe course, notably carrying a higher lymphoma risk.