[Substantiation of preclinical manifestations of bronchopulmonary diseases in workers exposed to organic dust].

144 workers of two Ukrainian fodder plants have been examined. Respiratory troubles presenting as cough, expectoration, shortness of breath have come to be the case from not only exposure to high concentrations of endotoxins but from low-level exposures as well. The prevalence of the toxic organic dust syndrome, musocal irritation syndrome, bronchial hyper-reactivity and obstructive changes in the ventilation function of the lungs have been found out to be associated with endotoxin levels in the air of the work environment of the production floor-area. Regarded as valid screenring procedures to early identify those persons predisposed to obstructive changes in the function of external respiration are pharmacological loading tests. Sanitary-and-hygienic and treatment-and-prophylactic measures are proposed to prevent development of occupational diseases in workers exposed to organic dust.