In vivo monitoring of organ-selective distribution of CdHgTe/SiO2 nanoparticles in mouse model.

CdHgTe/SiO(2) nanoparticles were prepared by SiO(2) capping on the surface of CdHgTe QDs. The characteristics, such as optical spectra, photostability, size and cell toxicity were investigated. The dynamic distribution of CdHgTe/SiO(2) nanoparticles was in vivo monitored by near infrared fluorescence imaging system. CdHgTe/SiO(2) nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 785 nm and high photo-stability. The hydrodynamic diameter of CdHgTe/SiO(2) nanoparticles could be adjusted to 122.3 nm. Compared to CdHgTe QDs, inhibitory effects of CdHgTe/SiO(2) nanoparticles on proliferation of HCT116 cells decreased to a certain extent. CdHgTe/SiO(2) nanoparticles had their specific dynamic distribution behavior, which provided new perspectives for bio-distribution of nanoparticles.