Underrated, Unvaccinated, Untreated: A Multinational Registry Analysis of Human Metapneumovirus in Hematological Malignancy, Insights From EPICOVIDEHA/EPIRESEHA Registry.
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Salmanton-García Jon, Marchesi Francesco, Mackenzie Erica, Heras-Fernando Inmaculada, Falces-Romero Iker, Vena Antonio, Garcia-Vidal Carolina, Weinbergerová Barbora, Sgherza Nicola, Piukovics Klára, Méndez Gustavo Adolfo, Leotta Dario, López-García Alberto, Farina Francesca, Erben Nurettin, Bilgin Yavuz M, Biernat Monika M, Petzer Verena, Magliano Gabriele, Drgoňa Ľuboš, Víšek Benjamín, Soto-Silva Andrés, Samarkos Michail, Navrátil Milan, Lahmer Tobias, Fracchiolla Nicola S, Vinh Donald C, Prezioso Lucia, Pantić Nikola, Khostelidi Sofya, Khedr Reham Abdelaziz, Eisa Noha, Dargenio Michelina, Buquicchio Caterina, Pinczés László Imre, Papa Mario Virgilio, García-Ramírez Patricia, Dąbrowska-Iwanicka Anna, Cuccaro Annarosa, Čolović Natasa, Čerňan Martin, Van Praet Jens, Valković Toni, Plantefeve Gaëtan, Merelli Maria, Labrador Jorge, Kolditz Martin, Glenthøj Andreas, Espigado Ildefonso, Erdem Simge, Drozd-Sokołowska Joanna, Delia Mario, Cerchione Claudio, Cattaneo Chiara, Batinić Josip, Avendaño Alejandro, Almasari Ahlam, Prin Romane, Nappi Davide, Musto Pellegrino, Hersby Ditte Stampe, Arellano Elena, Callejas-Charavia Marta, Varricchio Gina, Mitrović Mirjana, Anastasopoulou Amalia N, Wolf Dominik, Cordoba Raul, Romano Alessandra, Aiello Tommaso Francesco, Bavastro Martina, Limongelli Alessandro, Giordano Antonio, Brunetti Sara Caterina, Nguyen Kevin, Van Der Ven Lukas, Pagano Livio, Cornely Oliver A
Аннотация
METHOD: We performed a multicentre retrospective cohort study within the Epidemiology of COVID-19 in patients with hematological malignancies: A European Haematology Association Survey/ Epidemiology of respiratory viral infections in patients with hematological malignancies: A European Haematology Association Survey registry of haematological patients with hMPV (January 2023-December 2024), comparing clinical features and outcomes with matched influenza and SARS-CoV-2 cohorts.
RESULTS: The study included 130 patients with hMPV. Median age was 58.5 years; 57% were male. Plasma cell neoplasms (25%), lymphoma (23%), and acute myeloid leukemia (20%) were the most common hematological malignancies. Hospitalization occurred in 64%, intensive care unit (ICU) admission in 19%, and 30-day mortality was 8%. Most cases (73%) received supportive care only. Secondary infections were common (24%). Chronic renal disease significantly increased mortality risk (hazard ratio 20.9 11.05, P = .014). Compared with influenza and SARS-CoV-2, hMPV patients had comparable severity and outcomes, with 18.5% ICU admission rates versus 25.9% for influenza (P = .316) and 20.9% versus 4.7% for SARS-CoV-2 (P = .006), and 30-day mortality of 5.6% versus 11.1% for influenza (P = .489) and 7.0% versus 2.3% for SARS-CoV-2 (P = .277), yet received fewer targeted interventions.
CONCLUSIONS: hMPV causes clinically significant disease in patients with hematological malignancy, often necessitating hospital and ICU care, and leading to mortality. In the absence of specific treatments or vaccines, this virus remains an underrecognized pathogen in patients with hematological malignancy. Enhanced clinical awareness and investment in diagnostics, prevention, and therapeutics are needed.