Journal of infection and public health · 2025
West Nile Virus infection in the province of Seville. An emergent infection in Spain.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Caro-Leiro Ana, Martínez Pérez-Crespo Pedro María, Aguilar-Guisado Manuela, Roca Oporto Cristina, Lozano Domínguez Carmen, Merino Diaz Laura, Espíndola Gómez Reinaldo, Rubio Martín Elena, Luque-Ambrosiani Antonio Cristóbal, Ramírez de Arellano Encarnación, Infante Domínguez Carmen, Macías-Barrera María Carmen, Lepe José Antonio, Merchante Gutiérrez Nicolás, Cisneros José Miguel
Аннотация
INTRODUCTION: West Nile Virus (WNV) is becoming a severe problem in Europe. In 2020 and 2024, two unexpected and large outbreaks occurred in southern Spain, with a high rate of West Nile Neuroinvasive Disease (WNND).
OBJECTIVE: The aim of this study is to describe clinical and prognostic features of WNV infection.
MATERIALS AND METHODS: Retrospective multicentric cohort study of patients diagnosed with WNV infection in Seville (Spain) between 2020 and 2024.
RESULTS: 196 patients, 58.2 % of males, were diagnosed with WNV disease with a median age of 70 (49-78) for WNND and 46 (33-65) for West Nile Fever (WNF). One hundred eight patients (55.1 %) had associated comorbidity, including 22 (11.2 %) immunocompromised patients. 138 (70.4 %) patients required hospital admission with WNND (136, 69.4 %) as the main clinical syndrome, and 33 (16.8 %) were admitted to the ICU. Twenty-five patients (12.7 %) died during their admission; all of these patients had WNND. Twenty-one of the deaths (84 %) were directly related to meningoencephalitis. One hundred (58.5 %) of the survivors had sequelae at discharge.
CONCLUSION: In Spain, the first two large and unexpected outbreaks of WNV infection occurred in 2020 and 2024, resulting in high morbidity and mortality.
OBJECTIVE: The aim of this study is to describe clinical and prognostic features of WNV infection.
MATERIALS AND METHODS: Retrospective multicentric cohort study of patients diagnosed with WNV infection in Seville (Spain) between 2020 and 2024.
RESULTS: 196 patients, 58.2 % of males, were diagnosed with WNV disease with a median age of 70 (49-78) for WNND and 46 (33-65) for West Nile Fever (WNF). One hundred eight patients (55.1 %) had associated comorbidity, including 22 (11.2 %) immunocompromised patients. 138 (70.4 %) patients required hospital admission with WNND (136, 69.4 %) as the main clinical syndrome, and 33 (16.8 %) were admitted to the ICU. Twenty-five patients (12.7 %) died during their admission; all of these patients had WNND. Twenty-one of the deaths (84 %) were directly related to meningoencephalitis. One hundred (58.5 %) of the survivors had sequelae at discharge.
CONCLUSION: In Spain, the first two large and unexpected outbreaks of WNV infection occurred in 2020 and 2024, resulting in high morbidity and mortality.