Characterising model dynamics using sparse grid interpolation: Parameter estimation of cholera.

Sparse grid interpolation is a popular numerical discretization technique for the treatment of high dimensional, multivariate problems. We consider the case of using time-series data to calibrate epidemiological models from both phenomenological and mechanistic perspectives using this computational tool. By capturing the dynamics underlying both global and local spaces, our algorithm identifies potentially optimal regions of the parameter space and directs computational effort towards resolving the dynamics and resulting fits of these regions. We demonstrate how sparse grid interpolants can be effectively deployed to fit available data and discriminate between competing hypotheses to explain the current cholera epidemic in Yemen.