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American journal of hematology · 2024

Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.

СтатьяНазвание и аннотация: Перевод в очереди
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Salmanton-García Jon, Marchesi Francesco, Navrátil Milan, Piukovics Klára, Del Principe Maria Ilaria, Criscuolo Marianna, Bilgin Yavuz M, Fracchiolla Nicola S, Vena Antonio, Romano Alessandra, Falces-Romero Iker, Sgherza Nicola, Heras-Fernando Inmaculada, Biernat Monika M, Petzer Verena, Žák Pavel, Weinbergerová Barbora, Samarkos Michail, Erben Nurettin, van Praet Jens, López-García Alberto, Labrador Jorge, Lahmer Tobias, Drgoňa Ľuboš, Merelli Maria, Cuccaro Annarosa, Martín-Pérez Sonia, Dávila-Valls Julio, Farina Francesca, Cattaneo Chiara, Pinczés László Imre, Magyari Ferenc, Espigado Ildefonso, Buquicchio Caterina, Vinh Donald C, Stoma Igor, Čerňan Martin, Prezioso Lucia, Papa Mario Virgilio, Plantefeve Gaëtan, Khedr Reham Abdelaziz, Batinić Josip, Magliano Gabriele, Erdem Simge, Khostelidi Sofya, Čolović Natasha, Nappi Davide, García-Ramírez Patricia, Góra Jakub, Callejas-Charavia Marta, Tłusty Jędrzej, Bakker Martijn, Wojtyniak Elwira, Antić Darko, Magdziak Agnieszka, Dargenio Michelina, Idrizović Larisa, Pantić Nikola, Stojanoski Zlate, Eisa Noha, Otašević Vladimir, Marchetti Monia, Mackenzie Erica, Garcia-Vidal Carolina, Aujayeb Avinash, Almasari Ahlam, Miranda-Castillo Carolina, Gavriilaki Eleni, Coppola Nicola, Busca Alessandro, Adžić-Vukičević Tatjana, Schönlein Martin, Hersby Ditte Stampe, Gräfe Stefanie K, Glenthøj Andreas, Aiello Tommaso Francesco, Cvetanoski Milche, Mitrović Mirjana, Cerchione Claudio, Prin Romane, Varricchio Gina, Arellano Elena, Córdoba Raúl, Mayer Jiří, Víšek Benjamín, Wolf Dominik, Anastasopoulou Amalia N, Delia Mario, Musto Pellegrino, Leotta Dario, Bavastro Martina, Limongelli Alessandro, Sciumè Mariarita, van den Ven Lukas, Fianchi Luana, Brunetti Sara Caterina, Drozd-Sokołowska Joanna, Dąbrowska-Iwanicka Anna, Cornely Oliver A, Pagano Livio

Аннотация

Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.

Предметные рубрики MeSH

HumansHematologic NeoplasmsMaleFemaleMiddle AgedSeasonsAgedRespiratory Tract InfectionsAdultRegistriesRisk FactorsHospitalizationCommunity-Acquired InfectionsInfluenza, HumanAged, 80 and overVirus DiseasesCOVID-19