Novel risk loci for COVID-19 hospitalization among admixed American populations.
Diz-de Almeida Silvia, Cruz Raquel, Luchessi Andre D, Lorenzo-Salazar José M, de Heredia Miguel López, Quintela Inés, González-Montelongo Rafaela, Nogueira Silbiger Vivian, Porras Marta Sevilla, Tenorio Castaño Jair Antonio, Nevado Julian, Aguado Jose María, Aguilar Carlos, Aguilera-Albesa Sergio, Almadana Virginia, Almoguera Berta, Alvarez Nuria, Andreu-Bernabeu Álvaro, Arana-Arri Eunate, Arango Celso, Arranz María J, Artiga Maria-Jesus, Baptista-Rosas Raúl C, Barreda-Sánchez María, Belhassen-Garcia Moncef, Bezerra Joao F, Bezerra Marcos A C, Boix-Palop Lucía, Brion María, Brugada Ramón, Bustos Matilde, Calderón Enrique J, Carbonell Cristina, Castano Luis, Castelao Jose E, Conde-Vicente Rosa, Cordero-Lorenzana M Lourdes, Cortes-Sanchez Jose L, Corton Marta, Darnaude M Teresa, De Martino-Rodríguez Alba, Del Campo-Pérez Victor, de Bustamante Aranzazu Diaz, Domínguez-Garrido Elena, Eirós Rocío, Fariñas María Carmen, Fernandez-Nestosa María J, Fernández-Robelo Uxía, Fernández-Rodríguez Amanda, Fernández-Villa Tania, Gago-Dominguez Manuela, Gil-Fournier Belén, Gómez-Arrue Javier, Álvarez Beatriz González, Bernaldo de Quirós Fernan Gonzalez, González-Neira Anna, González-Peñas Javier, Gutiérrez-Bautista Juan F, Herrero María José, Herrero-Gonzalez Antonio, Jimenez-Sousa María A, Lattig María Claudia, Borja Anabel Liger, Lopez-Rodriguez Rosario, Mancebo Esther, Martín-López Caridad, Martín Vicente, Martinez-Nieto Oscar, Martinez-Lopez Iciar, Martinez-Resendez Michel F, Martinez-Perez Angel, Mazzeu Juliana F, Macías Eleuterio Merayo, Minguez Pablo, Cuerda Victor Moreno, Oliveira Silviene F, Ortega-Paino Eva, Parellada Mara, Paz-Artal Estela, Santos Ney P C, Pérez-Matute Patricia, Perez Patricia, Pérez-Tomás M Elena, Perucho Teresa, Pinsach-Abuin Mellina, Pita Guillermo, Pompa-Mera Ericka N, Porras-Hurtado Gloria L, Pujol Aurora, León Soraya Ramiro, Resino Salvador, Fernandes Marianne R, Rodríguez-Ruiz Emilio, Rodriguez-Artalejo Fernando, Rodriguez-Garcia José A, Ruiz-Cabello Francisco, Ruiz-Hornillos Javier, Ryan Pablo, Soria José Manuel, Souto Juan Carlos, Tamayo Eduardo, Tamayo-Velasco Alvaro, Taracido-Fernandez Juan Carlos, Teper Alejandro, Torres-Tobar Lilian, Urioste Miguel, Valencia-Ramos Juan, Yáñez Zuleima, Zarate Ruth, de Rojas Itziar, Ruiz Agustín, Sánchez Pascual, Real Luis Miguel, SCOURGE Cohort Group, Guillen-Navarro Encarna, Ayuso Carmen, Parra Esteban, Riancho José A, Rojas-Martinez Augusto, Flores Carlos, Lapunzina Pablo, Carracedo Ángel
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Аннотация
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.
Для цитирования: Diz-de Almeida Silvia, Cruz Raquel, Luchessi Andre D, Lorenzo-Salazar José M, de Heredia Miguel López, Quintela Inés, González-Montelongo Rafaela, Nogueira Silbiger Vivian, Porras Marta Sevilla, Tenorio Castaño Jair Antonio, Nevado Julian, Aguado Jose María, Aguilar Carlos, Aguilera-Albesa Sergio, Almadana Virginia, Almoguera Berta, Alvarez Nuria, Andreu-Bernabeu Álvaro, Arana-Arri Eunate, Arango Celso, Arranz María J, Artiga Maria-Jesus, Baptista-Rosas Raúl C, Barreda-Sánchez María, Belhassen-Garcia Moncef, Bezerra Joao F, Bezerra Marcos A C, Boix-Palop Lucía, Brion María, Brugada Ramón, Bustos Matilde, Calderón Enrique J, Carbonell Cristina, Castano Luis, Castelao Jose E, Conde-Vicente Rosa, Cordero-Lorenzana M Lourdes, Cortes-Sanchez Jose L, Corton Marta, Darnaude M Teresa, De Martino-Rodríguez Alba, Del Campo-Pérez Victor, de Bustamante Aranzazu Diaz, Domínguez-Garrido Elena, Eirós Rocío, Fariñas María Carmen, Fernandez-Nestosa María J, Fernández-Robelo Uxía, Fernández-Rodríguez Amanda, Fernández-Villa Tania, Gago-Dominguez Manuela, Gil-Fournier Belén, Gómez-Arrue Javier, Álvarez Beatriz González, Bernaldo de Quirós Fernan Gonzalez, González-Neira Anna, González-Peñas Javier, Gutiérrez-Bautista Juan F, Herrero María José, Herrero-Gonzalez Antonio, Jimenez-Sousa María A, Lattig María Claudia, Borja Anabel Liger, Lopez-Rodriguez Rosario, Mancebo Esther, Martín-López Caridad, Martín Vicente, Martinez-Nieto Oscar, Martinez-Lopez Iciar, Martinez-Resendez Michel F, Martinez-Perez Angel, Mazzeu Juliana F, Macías Eleuterio Merayo, Minguez Pablo, Cuerda Victor Moreno, Oliveira Silviene F, Ortega-Paino Eva, Parellada Mara, Paz-Artal Estela, Santos Ney P C, Pérez-Matute Patricia, Perez Patricia, Pérez-Tomás M Elena, Perucho Teresa, Pinsach-Abuin Mellina, Pita Guillermo, Pompa-Mera Ericka N, Porras-Hurtado Gloria L, Pujol Aurora, León Soraya Ramiro, Resino Salvador, Fernandes Marianne R, Rodríguez-Ruiz Emilio, Rodriguez-Artalejo Fernando, Rodriguez-Garcia José A, Ruiz-Cabello Francisco, Ruiz-Hornillos Javier, Ryan Pablo, Soria José Manuel, Souto Juan Carlos, Tamayo Eduardo, Tamayo-Velasco Alvaro, Taracido-Fernandez Juan Carlos, Teper Alejandro, Torres-Tobar Lilian, Urioste Miguel, Valencia-Ramos Juan, Yáñez Zuleima, Zarate Ruth, de Rojas Itziar, Ruiz Agustín, Sánchez Pascual, Real Luis Miguel, SCOURGE Cohort Group, Guillen-Navarro Encarna, Ayuso Carmen, Parra Esteban, Riancho José A, Rojas-Martinez Augusto, Flores Carlos, Lapunzina Pablo, Carracedo Ángel. Novel risk loci for COVID-19 hospitalization among admixed American populations.. eLife. 2024. DOI: 10.7554/elife.93666.
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