Resuscitation · 2019
Neonates with a 10-min Apgar score of zero: Outcomes by gestational age.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhong You Jia, Claveau Martine, Yoon Eugene W, Aziz Khalid, Singhal Nalini, Shah Prakesh S, Wintermark Pia, Canadian Neonatal Network (CNN) Investigators
Аннотация
BACKGROUND: The current resuscitation guidelines for neonates recommend considering stopping resuscitation efforts if the heart rate remains undetectable after 10 min of adequate resuscitation. However, this recommendation does not take into account the gestational age (GA) of the neonates. We determined the outcomes of neonates with a 10-min Apgar score of zero (Apgar10 = 0) with respect to their GA.
METHODS: In a retrospective matched cohort study, we studied neonates admitted to the Canadian Neonatal Network NICUs between 2010 and 2016 with an Apgar10 = 0. The neonates were divided into 3 subgroups according to their GA: (1) ≥36 weeks', (2) 320/7-356/7 weeks', and (3) <32 weeks'. Each neonate with Apgar10 = 0 was matched 1:1 with neonates of same GA and sex but Apgar10 = 1-2 and Apgar10 = 3-5. Survival and brain injury were compared between matched groups.
RESULTS: 177 neonates had Apgar10 = 0. Survival to discharge was significantly different between GA groups [≥36 weeks' 61% vs. 320/7-356/7 weeks' 58% vs. <32 weeks' 35%, p = 0.04]. Survival to discharge was similar to their matched cohort with Apgar10 = 1-2 for neonates born at ≥36 weeks' (61% vs. 66%) and between 320/7 to 356/7 weeks' (58% vs. 54%), but significantly different for neonates <32 weeks (35% vs. 61%, p = 0.04).
CONCLUSION: Neonates with Apgar10 = 0 had different outcomes depending on their GA. Less than half of neonates born at <32 weeks GA survived; however, a majority of neonates born at 320/7-356/7 weeks' and ≥36 weeks' GA survived at similar rates than their matched neonates with Apgar10 = 1-2.
METHODS: In a retrospective matched cohort study, we studied neonates admitted to the Canadian Neonatal Network NICUs between 2010 and 2016 with an Apgar10 = 0. The neonates were divided into 3 subgroups according to their GA: (1) ≥36 weeks', (2) 320/7-356/7 weeks', and (3) <32 weeks'. Each neonate with Apgar10 = 0 was matched 1:1 with neonates of same GA and sex but Apgar10 = 1-2 and Apgar10 = 3-5. Survival and brain injury were compared between matched groups.
RESULTS: 177 neonates had Apgar10 = 0. Survival to discharge was significantly different between GA groups [≥36 weeks' 61% vs. 320/7-356/7 weeks' 58% vs. <32 weeks' 35%, p = 0.04]. Survival to discharge was similar to their matched cohort with Apgar10 = 1-2 for neonates born at ≥36 weeks' (61% vs. 66%) and between 320/7 to 356/7 weeks' (58% vs. 54%), but significantly different for neonates <32 weeks (35% vs. 61%, p = 0.04).
CONCLUSION: Neonates with Apgar10 = 0 had different outcomes depending on their GA. Less than half of neonates born at <32 weeks GA survived; however, a majority of neonates born at 320/7-356/7 weeks' and ≥36 weeks' GA survived at similar rates than their matched neonates with Apgar10 = 1-2.