Frontiers in immunology · 2024
Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers.
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Poveda Eva, Fitzgerald Wendy, Alonso-Domínguez Jacobo, Aguayo-Arjona José, Mariño Ana, Álvarez Hortensia, Valcarce Nieves, Pérez Alexandre, Ruiz-Mateos Ezequiel, Margolis Leonid, Lederman Michael M, Freeman Michael L
Аннотация
Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.