Current medicinal chemistry · 2025
Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lavrenov Sergey N, Simonov Alexander Yu, Panov Alexey A, Solovieva Svetlana E, Mantsyzov Alexey B, Churakov Andrei V, Trenin Alexey S, Levshin Igor B
Аннотация
INTRODUCTION: A new series of triazoles with antifungal activity have been synthesized in a one-step fashion by direct reaction of 2-(2,4-difluorophenyl)-2,3-epoxy- 1-(1H-1,2,4-triazol-1-yl)propane with various diamines.
METHODS: Obtained compounds were profiled for biological activity against pathogenic strains of fungi C. albicans and A. niger. Molecular modeling was used to predict binding modes.
RESULTS: The lead compound was 4 times more active against C. albicans than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of A. niger.
CONCLUSION: The results presented herein can contribute to the development of novel antifungal therapeutic agents.
METHODS: Obtained compounds were profiled for biological activity against pathogenic strains of fungi C. albicans and A. niger. Molecular modeling was used to predict binding modes.
RESULTS: The lead compound was 4 times more active against C. albicans than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of A. niger.
CONCLUSION: The results presented herein can contribute to the development of novel antifungal therapeutic agents.