Second TURB, restaging TURB or repeat TURB in primary T1 non-muscle invasive bladder cancer: impact on prognosis?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Beijert Irene J, Hentschel Anouk E, Bründl Johannes, Compérat Eva M, Plass Karin, Rodríguez Oscar, Subiela Henríquez Jose D, Hernández Virginia, de la Peña Enrique, Alemany Isabel, Turturica Diana, Pisano Francesca, Soria Francesco, Čapoun Otakar, Bauerová Lenka, Pešl Michael, Bruins H Maxim, Runneboom Willemien, Herdegen Sonja, Breyer Johannes, Brisuda Antonin, Calatrava Ana, Rubio-Briones José, Seles Maximilian, Mannweiler Sebastian, Bosschieter Judith, Kusuma Venkata R M, Ashabere David, Huebner Nicolai, Cotte Juliette, Contieri Roberto, Mertens Laura S, Claps Francesco, Masson-Lecomte Alexandra, Liedberg Fredrik, Cohen Daniel, Lunelli Luca, Cussenot Olivier, El Sheikh Soha, Volanis Dimitrios, Côté Jean-François, Rouprêt Morgan, Haitel Andrea, Shariat Shahrokh F, Mostafid A Hugh, Nieuwenhuijzen Jakko A, Zigeuner Richard, Dominguez-Escrig Jose L, Hacek Jaromir, Zlotta Alexandre R, Burger Maximilian, Evert Matthias, Hulsbergen-van de Kaa Christina A, van der Heijden Antoine G, Kiemeney Lambertus A L M, Soukup Viktor, Molinaro Luca, Gontero Paolo, Llorente Carlos, Algaba Ferran, Palou Joan, N'Dow James, Ribal Maria J, van der Kwast Theo H, Babjuk Marko, Sylvester Richard J, van Rhijn Bas W G
Аннотация
METHODS: Individual patient data with tumor characteristics of 1660 primary T1-patients (muscle-invasion at re-TURB omitted) diagnosed from 1990 to 2018 in 17 hospitals were analyzed. Time to recurrence, progression, death due to bladder cancer (BC), and all causes (OS) were visualized with cumulative incidence functions and analyzed by log-rank tests and multivariable Cox-regression models stratified by institution.
RESULTS: Median follow-up was 45.3 (IQR 22.7-81.1) months. There were no differences in time to recurrence, progression, or OS between patients undergoing restaging (135 patients), second (644 patients), or repeat-TURB (84 patients), nor between patients who did or who did not undergo second or restaging-TURB. However, patients who underwent repeat-TURB had a shorter time to BC death compared to those who had second- or restaging-TURB (multivariable HR 3.58, P = 0.004).
CONCLUSION: Prognosis did not significantly differ between patients who underwent restaging- or second-TURB. However, a worse prognosis in terms of death due to bladder cancer was found in patients who underwent repeat-TURB compared to second-TURB and restaging-TURB, highlighting the importance of separately evaluating different indications for re-TURB.