[The effects of PGI2 analog (OP-41483) on hemodynamics and myocardial metabolism during simple deep hypothermia].

The effects of PGI2 analog (OP-41483) on hemodynamics and myocardial metabolism were compared with those of triflupromazine in dogs under simple deep hypothermia. Twenty dogs were divided into two groups according to the agent administered. In group OP (n = 10), intravenous administration of OP-41483 was performed continuously during the procedure. While the bolus of intravenous triflupromazine was injected at the beginning of cooling in group TR (n = 10). 1) Systemic and coronary vascular resistance decreased during cooling period in group OP but it increased in group TR. 2) Myocardial lactate extraction ratio was higher in group OP compared with group TR, but the ratio remained above 10% in both groups. 3) No significant differences in mean coronary blood flow and myocardial oxygen consumption were noted between the two groups. The study suggests that OP-41483 is one of the useful agents to maintain coronary circulation and myocardial metabolism under simple deep hypothermia.