Bioscience, biotechnology, and biochemistry · 2005
FR207944, an antifungal antibiotic from Chaetomium sp. no. 217 I. Taxonomy, fermentation, and biological properties.
СтатьяНазвание и аннотация: Перевод в очереди
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Kobayashi Motoo, Kanasaki Ryuichi, Sato Ikuko, Abe Fumie, Nitta Kumiko, Ezaki Masami, Sakamoto Kazutoshi, Hashimoto Michizane, Fujie Akihiko, Hino Motohiro, Hori Yasuhiro
Аннотация
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus fumigatus and Candida albicans. Specifically, FR207944 exhibits in vitro and in vivo antifungal activity against A. fumigatus. The effects of FR207944 on the morphology of A. fumigatus were shown to be similar to those of FR901379, a known 1,3-beta-glucan synthase inhibitor. The MECs of FR207944 against A. fumigatus FP1305 and C. albicans FP633 in micro-broth dilution test were 0.039 and 1.6 mug/ml respectively. FR207944 showed good potency by subcutaneous injection and oral administration against A. fumigatus in a murine systemic infection model, with ED(50)s of 5.7 and 17 mg/kg respectively.