Lasers in surgery and medicine · 2006
Aspirin reduces platelet aggregation during high-energy excimer laser.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Ruiping, Patel Roshan B, Ma Hongbao, Taylor Kevin, Abela George S
Аннотация
BACKGROUND AND OBJECTIVES: Excimer laser is used clinically in arterial revascularization procedures. This study evaluated the efficacy of aspirin in reducing platelet aggregation during high-energy excimer lasing.
STUDY DESIGN/MATERIALS AND METHODS: Platelet rich plasma (PRP) from seven rabbits was circulated in a dual organ chamber with aspirin added to one and the other was control. PRP was irradiated using an excimer laser (308 nm; 45 mJ/mm(2); 25 Hz; 5 minutes) via a 2.0 mm laser catheter. Platelet aggregation (particle volume) was measured by laser-light scattering. Morphology was evaluated by phase contrast and electron microscopy.
RESULTS: Baseline platelet volume was 3.4 microm(3) for both control and aspirin groups. Following lasing, platelet volume peaked at 102.2 +/- 18.5 microm(3) for control compared to 43.1 +/- 49.2 microm(3) for aspirin-treated PRP (P < 0.0001).
CONCLUSION: Aspirin reduces large platelet aggregates but not small aggregates by 58% during lasing of PRP.
STUDY DESIGN/MATERIALS AND METHODS: Platelet rich plasma (PRP) from seven rabbits was circulated in a dual organ chamber with aspirin added to one and the other was control. PRP was irradiated using an excimer laser (308 nm; 45 mJ/mm(2); 25 Hz; 5 minutes) via a 2.0 mm laser catheter. Platelet aggregation (particle volume) was measured by laser-light scattering. Morphology was evaluated by phase contrast and electron microscopy.
RESULTS: Baseline platelet volume was 3.4 microm(3) for both control and aspirin groups. Following lasing, platelet volume peaked at 102.2 +/- 18.5 microm(3) for control compared to 43.1 +/- 49.2 microm(3) for aspirin-treated PRP (P < 0.0001).
CONCLUSION: Aspirin reduces large platelet aggregates but not small aggregates by 58% during lasing of PRP.