Медицинская библиотека · Fa yi xue za zhi · 2015

[Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats].

Luo Liang-ming, Gong Qun, Liu Jian-feng, Zhao Ming-quan, Chen Dong-dong, Xie Yao-yao, Zhu Hua

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Аннотация

OBJECTIVE

To observe the expression of discs large homolog 4 (DLG4) protein in hippocampus, amygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence.

METHODS

The rat heroin dependent model was established by increasing intraperitoneal injection of heroin. DLG4 proteins in hippocampus, amygdala and frontal cortex of heroin dependent 9, 18, 36 days rats were detected with immunohistochemical staining and compared with that in the control group.

RESULTS

DLG4 proteins in hippocampus, amygdala and frontal cortex were gradually reduced with extension of heroin dependent time.

CONCLUSION

Heroin dependence can affect postsynaptic density of hippocampus, amygdala and frontal cortex. The changes become more apparent with extension of heroin dependence time.

Для цитирования: Luo Liang-ming, Gong Qun, Liu Jian-feng, Zhao Ming-quan, Chen Dong-dong, Xie Yao-yao, Zhu Hua. [Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats].. Fa yi xue za zhi. 2015.

Предметные рубрики MeSH

Amygdala Animals Disks Large Homolog 4 Protein Frontal Lobe Heroin Heroin Dependence Hippocampus Injections, Intraperitoneal Intracellular Signaling Peptides and Proteins Membrane Proteins Rats

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