French survey of the first three-years of liver transplantation activity from uncontrolled donors deceased after cardiac death.

OBJECTIVE

To assess the first three years of French activity related to liver transplantation from uncontrolled donation after cardiac death (uDCD).

STUDY

DESIGN

Prospective and observational study in the three active centres authorized by the French Biomedicine Agency.

PATIENTS AND

METHODS

All patients deceased between 2010 and 2012 after an uncontrolled cardiac arrest admitted to one of three centres (Pitié-Salpêtrière, Saint-Louis or Bicêtre hospitals, AP-HP, Paris, France) and potentially eligible for liver recovery were included. Abdominal normothermic oxygenated recirculation (ANOR) was used for graft preservation.

RESULTS

One hundred twenty-six potential uDCD donors were identified as eligible for liver recovery after hospital admission. The main causes of organ recovery failure were technical failure related to ANOR (29 patients, 23%), refusal of consent (39 patients, 31% of potential uDCD donors and 40% of asked relatives) and abnormal hepatic transaminases up to 200 UI.L(-1) during ANOR (24 patients, 19%). Finally, 11 livers were transplanted. Process efficiency was 9% [95% CI: 4-15%]. One-year recipient survival was 82%, [95% CI: 48-98%] and one-year graft survival was 64% [95% CI: 31-89%].

CONCLUSION

Liver transplantation from uDCD donors is achievable in France, despite low process efficiency.