Annals of hepatology · 2016
Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis.
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Díaz Francia C, Sáez-González Esteban, Benlloch Salvador, Álvarez-Sotomayor Diego, Conde Isabel, Polo Begoña, García María, Rodríguez María, Prieto Martín
Аннотация
UNLABELLED: Background and aims. Steroid-related hepatotoxicity has become one of the most relevant causes of drug induced liver cholestasis. Some patients do not improve after standard medical treatment (SMT) and may therefore require other approaches, like extracorporeal liver support.
MATERIAL AND METHODS: We report four cases of patients with pruritus, abnormal liver function tests and biopsy-proven anabolic steroid-induced cholestasis who were unresponsive to SMT. They underwent treatment with albumin dialysis (Molecular Adsorbent Recirculating System -MARS®-). A minimum of two MARS sessions were performed.
RESULTS: After MARS® procedure, patients' symptoms improved, as well as liver function tests, thus avoiding liver transplantation.
CONCLUSION: Albumin dialysis appears as a valuable therapeutic option for the management of anabolic steroid-induced cholestasis in patients that are unresponsive to SMT.
MATERIAL AND METHODS: We report four cases of patients with pruritus, abnormal liver function tests and biopsy-proven anabolic steroid-induced cholestasis who were unresponsive to SMT. They underwent treatment with albumin dialysis (Molecular Adsorbent Recirculating System -MARS®-). A minimum of two MARS sessions were performed.
RESULTS: After MARS® procedure, patients' symptoms improved, as well as liver function tests, thus avoiding liver transplantation.
CONCLUSION: Albumin dialysis appears as a valuable therapeutic option for the management of anabolic steroid-induced cholestasis in patients that are unresponsive to SMT.
Предметные рубрики MeSH
AdultAnabolic AgentsAndrostanolsChemical and Drug Induced Liver InjuryCholestasis, IntrahepaticHumansLiver Function TestsMaleMembranes, ArtificialProtein BindingPruritusRecovery of FunctionSerum AlbuminSerum Albumin, HumanSorption DetoxificationTestosterone CongenersTime FactorsTreatment OutcomeYoung Adult