MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1084/jem.20230661

Медицинская библиотека · The Journal of experimental medicine · 2023

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.

Gervais Adrian, Rovida Francesca, Avanzini Maria Antonietta, Croce Stefania, Marchal Astrid, Lin Shih-Ching, Ferrari Alessandro, Thorball Christian W, Constant Orianne, Le Voyer Tom, Philippot Quentin, Rosain Jérémie, Angelini Micol, Pérez Lorenzo Malena, Bizien Lucy, Achille Cristian, Trespidi Francesca, Burdino Elisa, Cassaniti Irene, Lilleri Daniele, Fornara Chiara, Sammartino José Camilla, Cereda Danilo, Marrocu Chiara, Piralla Antonio, Valsecchi Chiara, Ricagno Stefano, Cogo Paola, Neth Olaf, Marín-Cruz Inés, Pacenti Monia, Sinigaglia Alessandro, Trevisan Marta, Volpe Andrea, Marzollo Antonio, Conti Francesca, Lazzarotto Tiziana, Pession Andrea, Viale Pierluigi, Fellay Jacques, Ghirardello Stefano, Aubart Mélodie, Ghisetti Valeria, Aiuti Alessandro, Jouanguy Emmanuelle, Bastard Paul, Percivalle Elena, Baldanti Fausto, Puel Anne, MacDonald Margaret R, Rice Charles M, Rossini Giada, Murray Kristy O, Simonin Yannick, Nagy Anna, Barzon Luisa, Abel Laurent, Diamond Michael S, Cobat Aurélie, Zhang Shen-Ying, Casanova Jean-Laurent, Borghesi Alessandro

СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаПеревод в очереди

Аннотация

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.

Для цитирования: Gervais Adrian, Rovida Francesca, Avanzini Maria Antonietta, Croce Stefania, Marchal Astrid, Lin Shih-Ching, Ferrari Alessandro, Thorball Christian W, Constant Orianne, Le Voyer Tom, Philippot Quentin, Rosain Jérémie, Angelini Micol, Pérez Lorenzo Malena, Bizien Lucy, Achille Cristian, Trespidi Francesca, Burdino Elisa, Cassaniti Irene, Lilleri Daniele, Fornara Chiara, Sammartino José Camilla, Cereda Danilo, Marrocu Chiara, Piralla Antonio, Valsecchi Chiara, Ricagno Stefano, Cogo Paola, Neth Olaf, Marín-Cruz Inés, Pacenti Monia, Sinigaglia Alessandro, Trevisan Marta, Volpe Andrea, Marzollo Antonio, Conti Francesca, Lazzarotto Tiziana, Pession Andrea, Viale Pierluigi, Fellay Jacques, Ghirardello Stefano, Aubart Mélodie, Ghisetti Valeria, Aiuti Alessandro, Jouanguy Emmanuelle, Bastard Paul, Percivalle Elena, Baldanti Fausto, Puel Anne, MacDonald Margaret R, Rice Charles M, Rossini Giada, Murray Kristy O, Simonin Yannick, Nagy Anna, Barzon Luisa, Abel Laurent, Diamond Michael S, Cobat Aurélie, Zhang Shen-Ying, Casanova Jean-Laurent, Borghesi Alessandro. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.. The Journal of experimental medicine. 2023. DOI: 10.1084/jem.20230661.

Предметные рубрики MeSH

AnimalsChlorocebus aethiopsHumansWest Nile FeverWest Nile virusVero CellsAutoantibodiesAntibodies, ViralInterferon Type IInterferon-alpha
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.