Journal of neuroscience methods · 2018
Ensuring signal quality of cerebral near infrared spectroscopy during continuous longterm monitoring.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Govindan R B, Massaro A N, du Plessis Adre
Аннотация
BACKGROUND: Near infrared spectroscopy (NIRS) derived hemoglobin difference (HbD: oxygenated [HbO2] - reduced hemoglobin [Hb]) and total hemoglobin (HbT: HbO2+Hb) have been used as surrogate measures of cerebral blood flow and volume, respectively. Statistically, a lack of HbD-blood pressure (BP) or negative HbT-BP association is regarded as a state of intact cerebral pressure autoregulation (CPA). In contrast, a co-variation of HbD/HbT and systemic blood pressure (BP) in the same direction is thought of as a failure of CPA. If the quality of one (NIRS/BP) or both signals is compromised, the reliability of the results may be adversely affected. In this work, we develop an analytic approach to assess the quality of the NIRS signals.
NEW METHOD: Given that cardiac pulses cause hemodynamic changes that are transmitted through the peripheral vasculature, cerebral NIRS signals should exhibit cyclical changes at the pulse frequency. Therefore, we propose that an association between HbD/HbT and electrocardiogram (EKG) signals would be an indicator of NIRS quality. We demonstrate the application of this approach with data collected from six newborns undergoing therapeutic hypothermia for neonatal encephalopathy.
RESULTS: We observed an intermittent lack of association between NIRS signals and EKG data over the course of several hours of continuous records, indicating a loss in the strength in NIRS signals.
COMPARISON WITH EXISTING METHOD: Existing CPA characterization suffers from Type-II error which the current preprocessing approach can mitigate.
CONCLUSIONS: The proposed approach will allow for real-time assessment of NIRS signal quality that is essential for accurate CPA monitoring.
NEW METHOD: Given that cardiac pulses cause hemodynamic changes that are transmitted through the peripheral vasculature, cerebral NIRS signals should exhibit cyclical changes at the pulse frequency. Therefore, we propose that an association between HbD/HbT and electrocardiogram (EKG) signals would be an indicator of NIRS quality. We demonstrate the application of this approach with data collected from six newborns undergoing therapeutic hypothermia for neonatal encephalopathy.
RESULTS: We observed an intermittent lack of association between NIRS signals and EKG data over the course of several hours of continuous records, indicating a loss in the strength in NIRS signals.
COMPARISON WITH EXISTING METHOD: Existing CPA characterization suffers from Type-II error which the current preprocessing approach can mitigate.
CONCLUSIONS: The proposed approach will allow for real-time assessment of NIRS signal quality that is essential for accurate CPA monitoring.