Journal of medical case reports · 2011
Treatment with gefitinib after erlotinib-induced liver injury: a case report.
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Nakatomi Katsumi, Nakamura Yoichi, Tetsuya Iida, Kohno Shigeru
Аннотация
INTRODUCTION: Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver injury and was then treated with gefitinib without hepatic toxicity or disease progression is presented.
CASE PRESENTATION: A 31-year-old Japanese woman, who never smoked and who was diagnosed as having lung adenocarcinoma with carcinomatous meningitis, was treated with erlotinib. She developed erlotinib-induced liver injury after four weeks of treatment. The treatment was stopped right away, but the symptoms of meningitis re-appeared immediately. Gefitinib treatment was started and continued without recurrence of drug-induced liver injury.
CONCLUSION: Gefitinib appears to be a potential treatment option after erlotinib-induced liver injury.
CASE PRESENTATION: A 31-year-old Japanese woman, who never smoked and who was diagnosed as having lung adenocarcinoma with carcinomatous meningitis, was treated with erlotinib. She developed erlotinib-induced liver injury after four weeks of treatment. The treatment was stopped right away, but the symptoms of meningitis re-appeared immediately. Gefitinib treatment was started and continued without recurrence of drug-induced liver injury.
CONCLUSION: Gefitinib appears to be a potential treatment option after erlotinib-induced liver injury.