Molecules (Basel, Switzerland) · 2024
Anti-Inflammatory and Antioxidative N-Acetyldopamine Dimers from Adult Vespa velutina auraria Smith.
СтатьяНазвание и аннотация: Перевод в очереди
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Liu Chao-He, Pang Xiu-Qing, Yu Qun, Zhang Wei, Xu Jing-Lei, Ma Yu-Chen, Huang Lei, Huang Geng, Wang Jia-Peng, Xiao Huai, Ding Zhong-Tao
Аннотация
One undescribed fatty glyceride (1), two unreported N-acetyldopamine dimers (2 and 3), and four known structurally diverse N-acetyldopamine dimers were isolated from adult Vespa velutina auraria Smith. Their structures were elucidated based on a comprehensive analysis of spectroscopic data, HRESIMS, and NMR calculations with ML_J_DP4, and the absolute configurations of 2 and 3 were determined via ECD calculations. Regarding their bioactivities, compounds 5 and 6 can inhibit the production of NO. Moreover, compounds 3, 5 and 7 showed stronger antioxidant activity than the positive control (VC) at 14 μg/mL. A network pharmacology study was used to explore the potential bioactive mechanisms. In addition, a docking study of anti-inflammatory and antioxidative compounds was also performed.