The Annals of otology, rhinology, and laryngology · 2008
Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Omori Koichi, Tada Yasuhiro, Suzuki Teruhisa, Nomoto Yukio, Matsuzuka Takashi, Kobayashi Ken, Nakamura Tatsuo, Kanemaru Shinichi, Yamashita Masaru, Asato Ryo
Аннотация
OBJECTIVES: The objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue.
METHODS: We have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.
RESULTS: In 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cricoid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.
CONCLUSIONS: Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.
METHODS: We have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.
RESULTS: In 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cricoid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.
CONCLUSIONS: Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.